Uechi, H. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-025-01893-5 (2025).
Bravo-Jimenez, M. A., Sharma, S. & Karimi-Abdolrezaee, S. Mol. Neurodegener. 20, 20 (2025).
Google…
Category: 5. Biology
-
Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory
Ranganath, C. Binding items and contexts: The cognitive neuroscience of episodic memory. Curr. Directions Psychological Sci. 19, 131–137 (2010).
Yim, H., Dennis, S. J. & Sloutsky, V. M. The…
Continue Reading
-
An enzyme for high-yield, ATP-driven C-terminal thioester generation
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Frazier, C. L. et al. Engineered reactivity of a bacterial E1-like enzyme enables…
Continue Reading
-
Aberrant protein translation promotes T cell exhaustion
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Liu, Y. et al. LARP4-mediated hypertranslation drives T cell dysfunction in tumors….
Continue Reading
-
Triple-effect correction for Cell Painting data with contrastive and domain-adversarial learning
This research does not involve human participants, animal subjects, or the use of biological samples requiring institutional ethics approval. All relevant ethical regulations were followed.
Overview of cpDistiller
cpDistiller consists of three main…
Continue Reading
-
Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis
Patients
Paraffin-embedded samples of 50 primary DLBCL patients and 30 reactive hyperplasia patients in Shandong Provincial Hospital between 2014 and 2019 were collected. Samples of reactive hyperplasia were used as controls. Peripheral blood,…
Continue Reading
-
Structural basis for mTORC1 regulation by the CASTOR1–GATOR2 complex
Cloning and protein purification
GATOR2 purification
Codon-optimized DNA encoding all five subunits of GATOR2 (MIOS, WDR59, WDR24, SEH1L and Sec13) was synthesized by Twist Biosciences and subcloned into the pCAG vector. The construct with MIOS was…
Continue Reading
-
Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state
Engineering patterned ECM substrates of defined area
To create defined areas of ECM proteins, we used μCP to print arrays of circular collagen I patterns to which HeLa (Kyoto) cells can adhere via α1β1 and α2β1 integrins57 and circular…
Continue Reading
-
Inflammation sends old muscle stem cells into a rusty meltdown
Inflammation sends old muscle stem cells into a rusty meltdown
Continue Reading
-
Development of a time-resolved fluorescence-based lateral flow immunoassay for rapid and sensitive diagnosis of Middle East respiratory syndrome
Production of N protein antigen
The full-length N gene of MERS-CoV was synthesized and cloned into the pET28a vector harboring an N-terminal 6×His tag. Then, the N-terminal domain (NTD, 1-492 nucleotide) and C-terminal domain (CTD, 502–1239…
Continue Reading