Identification of gene subtypes based on MRGs
Employing the ConsensusClusterPlus algorithm, we stratified KIRC patients into two molecularly distinct subtypes (C1 and C2) based on MRG expression profiles (Fig. 1A). Kaplan-Meier survival analysis…
Category: 5. Biology
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Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to inhibit apoptosis
Compounds, reagents, and antibodies
Salidroside (Cat: HY-N0109), Metformin (Cat: HY-B0627), Streptozotocin (STZ, Cat: HY-13753), and Z-DEVD- FMK (Cat: HY-12466) were purchased from MCE (USA), with 99.79%, 99.98%, 99.15%, and 98% purity,…
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A triple pronged approach for ulcerative colitis severity classification using multimodal, meta, and transformer based learning
Problem formulation
For the classification of ulcerative colitis (UC) severity into two categories, mild and severe, we define the dataset as \({D} = \{(x_i, y_i)\}_{i=1}^N\), where \(x_i\) represents the input images and \(y_i \in \{0, 1\}\)…
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Identification of multiple genomic alterations and prediction of neoantigens from circulating tumor cells at the single-cell level
Ethics statement
This study complies with all relevant ethical regulations for research involving human participants and animals. Ethical approval for all human studies was obtained from the Research Ethics Committee of Shanghai General Hospital,…
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Single-cell transcriptomics of ventral forebrain progenitors identifies Evf2 enhancer lncRNA-enhancer gene guidance through direct RNA binding and RNP recruitment domains
Cellular heterogeneity masks the extent of Evf2 transcriptional regulation in mouse E13.5 ganglionic eminences
Chromosome conformation capture (4Cseq) studies using Dlx5/6UCE as the bait identified 129 Evf2-regulated Dlx5/6UCE sites located within…
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Scientists Solve Decades-Old Photosynthesis Mystery
Scientists have uncovered why a critical part of photosynthesis only uses one of two seemingly identical pathways, revealing hidden energy barriers and structural nuances that could help engineer more efficient artificial systems. Scientists from…
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Amazon River Yields Surprise As Drones Spot 41,000 Rare Turtles
Scientists have developed a drone-based counting method that corrected major errors in traditional wildlife surveys. Researchers from the University of Florida have created a more precise method for counting wildlife using drones. This…
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How a Human Protein Helps Turn a Fungus Into a Pathogen
Our bodies host a variety of microorganisms, and the microbial communities in and on our bodies have to maintain the right balances among their members, or problems can arise. This includes the overgrowth of…
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This desert beetle runs to cool off
In the hot dunes of Southern Africa’s Namib Desert, the black beetle Onymacris plana runs fast for its tiny size. Turns out, the speed not only helps the beetles find food but also, perhaps, cool down. The beetles’ temperature drops…
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AI Decodes the Secret Language of Your Gut Bacteria
A neural network analyzes an extensive gut microbiome dataset to uncover insights into human health. Gut bacteria play an important role in a wide range of health conditions. Their sheer diversity and the complexity of their interactions with…
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