Category: 5. Biology

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  • Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

    Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

    Establishment of the ZZW-115 resistant cells

    To model the emergence of therapeutic resistance in a manner that more closely reflects clinical tumor evolution, we chose to generate ZZW-115-resistant cells through a population-based adaptive…

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  • Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis

    Impact of gut microbiome on radiotherapy and immunotherapy efficacy in microsatellite-stable colorectal cancer: role of propionic acid and B. fragilis

    Cell culture and bacterial culture

    CT26 cell line was provided by the Department of Pathology of Nanfang Hospital with STR profiling and cultured in Dulbecco’s Modified Eagle’s Medium (DMEM, Gibco, Grand Island, NY, USA) supplemented with 10%…

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  • Association between vitamin D receptor FokI gene polymorphism and risk of type 2 diabetes mellitus in the Ethiopian population

    Association between vitamin D receptor FokI gene polymorphism and risk of type 2 diabetes mellitus in the Ethiopian population

  • Othman, G. O., Aali, M. H., Saeed, C. H. & Najeeb, H. A. Vitamin D receptor gene ApaI and TaqI polymorphism in patients with type II diabetes mellitus using Pcr-Rflp method in Kurdistan region. 17(1) (2023).

  • Mohammed, A. A. et al. Allelic…

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  • Evidential deep learning-based drug-target interaction prediction

    Evidential deep learning-based drug-target interaction prediction

    Datasets

    Three datasets DrugBank68, Davis59, and KIBA60 were used for model evaluation. Supplementary Table 1 summarizes these datasets.

    DrugBank: the data used in this study were published on January 3, 2020 (version 5.1.5). Drugs with inorganic…

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  • Inoculation with Talaromyces trachyspermus and arbuscular mycorrhizal fungus alongside sulfonylurea herbicides alters Orobanche aegyptiaca and tomato growth

    Inoculation with Talaromyces trachyspermus and arbuscular mycorrhizal fungus alongside sulfonylurea herbicides alters Orobanche aegyptiaca and tomato growth

    The mycorrhizal colonization rate was found to be significantly influenced by fungi and herbicides (P ≤ 0.01). However, the application methods of the herbicides were not effective in the greenhouse experiment. In plants that were not…

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  • Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome

    Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome

  • Boyle, J. A. & Teede, H. J. PCOS: refining diagnostic features in PCOS to optimize health outcomes. Nat. Reviews Endocrinol. 12 (11), 630–631 (2016).

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  • Li, J. et al. Effect of exposure to…

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  • A complex between IF2 and NusA suggests early coupling of transcription-translation

    A complex between IF2 and NusA suggests early coupling of transcription-translation

    Labeling of IFs and fMet-tRNAfMet

    To fluorescence label the IFs for live-cell single-molecule tracking, we explored if the addition of a HaloTag compromises IF activity in supporting cell growth (Supplementary Note 1)….

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  • Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts

    Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts

    Whole blood transcriptomics

    Two participants provided three blood samples each (Fig. 1A). The blood samples were collected at the pre-flight mark (T0, within two weeks before departure), at post-flight (T2, within 24 hours after landing), and at…

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  • Removal of E. coli O157:H7 coliform bacteria from sewage wastewater using silver doped borate bioglass

    Removal of E. coli O157:H7 coliform bacteria from sewage wastewater using silver doped borate bioglass

    Preparation of BAgX BG samples

    Five types of silver-doped borate BG samples, BAg0, BAg1, BAg2, BAg3, and BAg4, were prepared by the melt-quenching method at high temperatures between 1100 and 1200 °C as spherical-shaped discs (Fig. 2). After the…

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