Smyrlaki, I. et al. Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR. Nat. Commun. 11, 4812 (2020).
Google Scholar
Bayart, J.-L….
Category: 5. Biology
-
So close yet so far apart: distinct flanking sequence recognition by DNMT3A and DNMT3B
To comprehensively evaluate the sequence selectivity of DNMT3 enzymes, we constructed eight enzyme–DNA complex models based on the available crystal structures: DNMT3A bound to CGC, CGT, CGA, CGG, and DNMT3B bound to CGG, CGT, CGA, CGC. In…
Continue Reading
-
Expanding the cytokine receptor alphabet reprograms T cells into diverse states
Mice
Female Thy1.2+ C57BL/6 (C57BL/6J) mice (aged 5–6 weeks) and female and male NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice (aged 5–7 weeks) were purchased from Jackson Laboratory. TCR-transgenic Thy1.1+ Pmel-1 mice (B6.Cg-Thy1a/Cy…
Continue Reading
-
Substrate stiffness regulates triple-negative breast cancer signaling through CXCR4 receptor dynamics
Cell culture
We purchased SUM149 cells from the ATCC (Manassas, VA) and cultured cells in F-12 media supplemented with 10% fetal bovine serum (FBS), 1% penicillin/streptomycin (Pen/Strep) (Thermo Fisher Scientific, Waltham, MA), 1% GlutaMAX…
Continue Reading
-
A transformative preclinical model of rheumatic heart disease
Rheumatic heart disease (RHD) remains the leading cause of acquired heart disease in individuals aged >25 years. Despite being preventable, this condition affects >40 million people worldwide, particularly in low-income countries. RHD is…
Continue Reading
-
Protein hydrolysates derived from residual after polysaccharide extraction of Chlorella vulgaris biomass improves yield and quality of baby leaf lettuce
Recovery of post aqueous extraction of Chlorella vulgaris residual biomass after polysaccharide extraction
The microalga used in this work, Chlorella vulgaris f. viridis Chodat (strain SAG 211 − 12), belongs to the Division Chlorophyta and…
Continue Reading
-
Turning back the clock on age-related neurodegeneration
Turning back the clock on age-related neurodegeneration
Continue Reading
-
Warm autumns could be a driver in monarch butterflies’ decline
Toastier fall weather might cause migrating monarch butterflies to wing it and change their flight plans, starting the countdown toward death.
Eastern monarchs captured during their autumn migration and exposed to warm temperatures…
Continue Reading
-
Early Primates Primarily Inhabited Cold and Temperate Climates, New Study Suggests
Textbooks often portray primates as originating, evolving, and dispersing exclusively within warm tropical forests. This tends to come from fossil evidence distributed across tropical latitudes. However, new research led by University of…
Continue Reading
-
Dolphin follows a whale all the way to the seafloor
From Indigenous stories and starring in movies, to singing popular songs and vital…
Continue Reading