Animals and OXA-induced AD model
C57BL/6 J WT mice were purchased from SLC Inc. (Shizuoka, Japan). Nlrp3–/–, Asc–/–, Casp1/11–/–, Il1b–/–, and Gsdmd–/– mice were kindly provided by Dr. V. M. Dixit (Genentech, San Francisco,…
Category: 5. Biology
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Long-term trends in human fatalities from human–elephant conflict in Chhattisgarh, India
In Chhattisgarh, various factors influence the overall pattern of HEC, particularly leading to incidents of human fatalities and injuries. Developmental activities including infrastructure projects, agricultural expansions, deforestation have…
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Comment on: Astaxanthin mitigates radiation-induced erectile dysfunction: protective effects on corpus cavernosum in a rat model
Ozgur G, Sahin B, Atasoy BM, Tomruk C, Sirin Tomruk C, Tavukcu HH, et al. Astaxanthin mitigates radiation-induced erectile dysfunction: protective effects on corpus cavernosum in a rat model. Int J Impot Res. 2025.
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A designer polyQ fusion protein modulates NF-κB signaling by sequestering P65/RelA into aggregates
Housmans, J. A. J., Wu, G., Schymkowitz, J. & Rousseau, F. A guide to studying protein aggregation. FEBS J. 290, 554–583. https://doi.org/10.1111/febs.16312 (2023).
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Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis
Mouse models of acute and chronic pancreatitis
In vivo experiments (approved by the II Local Ethics Committee in Krakow under approval numbers 226/2018, 106/2020, and 312/2021) were performed on male C57BL6J mice aged 6–8 weeks and weighing…
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A visualized machine learning model using noninvasive parameters to differentiate men with and without prostatic carcinoma before biopsy
This study developed a visualized machine learning XGBOOST model for assessing PCA risk in patients with moderate or severe BPH. The model was based on noninvasive parameters, including STK1p, age, FPSA, and FTPSA. The XGBOOST model was well…
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Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors
Ethical considerations
This project was undertaken following approval from the relevant bodies, including Kenya Medical Research Institute (KEMRI) Scientific Review Unit (Approval # KEMRI/RES/7/3/1 and KEMRI/SERU/CGHR/035/3864), Kenya’s National…
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Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer
Individuals and associated samples
The institutional review boards of Kyoto Prefectural University of Medicine (ERB-C-319-1) approved this study, and all experimental procedures adhered to corresponding guidelines and directives. Informed written…
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Fractures incidence and its association on mortality in multiple myeloma patients: a nationwide cohort study (CAREMM-2105 study)
Data source
This study used data from the KNHIS database, a comprehensive healthcare insurance system that provides healthcare coverage for all South Korean individuals. The database encompasses health-related information of approximately 50…
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Human population history on the North Coast of peru from Y chromosomes and mitogenomes
Stanish, C. The Origin of State Societies in South America. Annu. Rev. Anthropol. 30, 41–64 (2001).
Kosok, P. Life, Land and Water in Ancient Peru (Long Island University Press, 1965).
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