A new study offers the first direct evidence that deep-dwelling mesopelagic fish, which account for up to 94 percent of global fish biomass, excrete carbonate minerals at rates comparable to shallow-water species. The findings validate previous…
Category: 5. Biology
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Study Overturns Decades-Old Dogma: Scientists Discover “Hidden Organization” in Gene Regulation
Scientists have uncovered how a surprisingly structured protein helps disordered molecules regulate gene expression, upending previous ideas in molecular biology. Inside every human cell, proteins play a crucial role in determining which genes…
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Earth’s Underground Life Could Exist on Mars, Scientists Say
Researchers found that earthquake-driven rock fractures can power deep-Earth life by splitting water into energy-rich compounds. Chinese scientists have recently questioned the long-standing idea that “all life depends on sunlight.” In new…
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Biomechanical effects of medial osteoarthritis progression and UKA on knee lateral compartment using fibril-reinforced biphasic material in finite element study
Pritzker, K. P. et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthr. Cartil. 14, 13–29 (2006).
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Pauli, C. et al. Macroscopic and histopathologic analysis…
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Evolutionary trajectory and spread of respiratory syncytial virus group A in neonatal cohorts in Pakistan amidst the COVID-19 pandemic
RT-PCR positivity and RSV sequence diversity in the cohort:
From 2019 to 2022, 758 paediatric patients ages 0–24 months in six Pakistani hospitals were tested for RSV and Influenza (Fig. 1). Starting in September 2021, admitted patients were…
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Identification of a key smooth muscle cell subset driving ischemic cardiomyopathy progression through single-cell RNA sequencing
Overview of the study
Cardiomyopathy is strongly associated with ferroptosis. The scRNA-seq of 4,184 SMCs found that C6 S100A4 + SMCs were critical, exhibiting high expression of ferroptosis, oxidative stress, and inflammation, which we…
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Removal of promoter CpG methylation by epigenome editing reverses HBG silencing
HUDEP2 cell culture
Human umbilical cord blood derived 2 (HUDEP2) cells were grown in serum free expansion medium (SFEM, StemSpan #9650) supplemented with 50 ng/mL stem cell factor (R&D Systems, #255-SC-200/CF), 3 IU/mL erythropoietin…
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Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure
Intestinal IL-23 and IL-22 reparative responses are lost in HFD-fed DSS-treated mice
To assess the influence of HFD feeding on antimicrobial responses after intestinal damage, we used our previous model of feeding male C57BL/6 mice with a 10%…
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IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation
Animals and OXA-induced AD model
C57BL/6 J WT mice were purchased from SLC Inc. (Shizuoka, Japan). Nlrp3–/–, Asc–/–, Casp1/11–/–, Il1b–/–, and Gsdmd–/– mice were kindly provided by Dr. V. M. Dixit (Genentech, San Francisco,…
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Long-term trends in human fatalities from human–elephant conflict in Chhattisgarh, India
In Chhattisgarh, various factors influence the overall pattern of HEC, particularly leading to incidents of human fatalities and injuries. Developmental activities including infrastructure projects, agricultural expansions, deforestation have…
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