Epithelial proliferation is a key driver of glomerular injury in conditions such as collapsing glomerulopathy or crescentic glomerulonephritis. Two new studies, one led by Darren Yuen and the other by Pierre Isnard and Fabiola Terzi, highlight…
Category: 5. Biology
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Single-quantum sodium MRI at 3 T for separation of mono- and bi-T2 sodium signals
Theoretical development
Model of sodium MRI signals
We use a two-population model, Eq. (1), to describe the single-quantum sodium image signal, m(t), evolving with time t at an imaging voxel ∆V. Time t = 0 is at the center of excitation RF…
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Uncovering rain-fed resilience power of grass pea in Iran using AMMI, BLUP, and multi-trait stability parameters
MLM analysis of variance and PLS regression
Preliminary inspection of collected raw data showed E9 as an outlier environment and hence it was eliminated from further analysis. The simple ANOVA results pertaining to each environment, correlation…
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HAVIT: research on vision-language gesture interaction mechanism for smart furniture
Problem description
The three-dimensional space where smart furniture is located is defined as \(\Omega \in {\mathbb {R}}^3\). In this space, users interact with smart furniture through gestures, and the system needs to accurately map the captured…
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Environmental cues in different host niches shape the survival fitness of Staphylococcus aureus
Transposon sequencing reveals genetic remodeling important for S. aureus survival in intracellular infection
First, we established a cell infection model using a S. aureus transposon (Tn) mutant library and analyzed the genes required for the…
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PANoptosis in cancer: bridging molecular mechanisms to therapeutic innovations
Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12:31–46.
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Peng F, Liao M, Qin R, Zhu S, Peng C, Fu L, et al. Regulated cell death (RCD) in cancer: key…
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Spatiotemporal dynamics of benzylisoquinoline alkaloid gene expression and co-expression networks during Papaver Somniferum developmental stages
Transcriptome sequencing and gene expression analysis
This study performed 150 bp paired-end transcriptome sequencing on roots, stems, leaves, and fruits (ovaries) of P. somniferum across developmental stages, generating 2.32 billion raw reads….
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DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution
Ethical statement
The patient sample S0273026 was collected under approved protocols of the institutional review board (IRB, ID: 19-1164) of the University of Cologne and provided written informed consent to share potentially identifying…
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Myeloid cells in chronic liver inflammation
Marcellin P, Kutala BK. Liver diseases: a major, neglected global public health problem requiring urgent actions and large-scale screening. Liver Int. 2018;38:2–6.
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Younossi ZM, Wong…
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Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study
Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357–81.
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Di Martino A, Scheres…
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