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Category: 5. Biology
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mist: a hierarchical Bayesian framework for detecting differential DNA methylation dynamics in single-cell data
Deaton, A. M. & Bird, A. CpG islands and the regulation of transcription. Genes Dev. 25, 1010–1022 (2011).
Dor, Y. & Cedar, H. Principles of {DNA} methylation and their implications for…
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Cortical-limbic circuit dynamics of approach-avoidance conflict in humans
Dymond, S. & Roche, B. A contemporary behavior analysis of anxiety and avoidance. Behav. Anal. 32, 7–27 (2009).
Kirlic, N., Young, J. & Aupperle, R. L. Animal to human translational paradigms…
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Engineering gut biosensors | Nature Methods
The human gastrointestinal tract is a highly dynamic ecosystem composed of heterogeneous physical environments shaped by factors such as pH, oxygen levels and osmolality. During disease, gut physical parameters can shift, altering the composition…
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Long-lived retinal ganglion cells | Nature Methods
Incorporating vascular cells in retinal organoid culture extends the survival and improves the function of retinal ganglion cells (RGCs), offering the possibility of advantageous modeling of human retinal disease and development.
When asked about…
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Accelerating bioconjugate development through rapid exploratory screening and analytics
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Early-stage development of antibody–drug conjugates and complex bioconjugates requires the fast and reliable establishment of processes and analytical methods to support preclinical and first-in-human drug…
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XA-Novo: high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures
Lu, L. L., Suscovich, T. J., Fortune, S. M. & Alter, G. Beyond binding: antibody effector functions in infectious diseases. Nat. Rev. Immunol. 18, 46–61 (2018).
Oostindie, S. C., Lazar, G….
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Scientists Discover Second Pregnancy Rewires the Brain in New Ways
Pregnancy is known to reshape the brain, but new research reveals that these changes do not stop after the first child. Scientists at Amsterdam UMC have found that a second pregnancy also reshapes the female brain. Earlier work by the same…
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This 550-Million-Year-Old Creature May Already Have Had a Brain
Scientists have uncovered surprising complexity in a tiny sensory structure found in comb jellies, some of the oldest animals on Earth. New three-dimensional reconstructions of an important sensory organ in comb jellies reveal a level of…
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Bed Bugs Are Terrified of This Simple Thing, Study Finds
New research reveals that bed bugs strongly avoid water and moisture. People often dread bed bugs, and for good reason. Once these blood-feeding insects establish themselves inside a home, they can be extremely difficult to eliminate. However,…
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