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Di Martino A, Scheres…
Category: 5. Biology
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SNP rs615552 and lncRNA CDKN2B-AS1 influence brain cancer pathogenesis through multi-omic mechanisms
Multi-omics colocalization analysis reveals key genetic variants in brain cancer
eQTL analysis indicates that CDKN2A, CDKN2B, and CDKN2B-AS1 co-locate with brain cancer(Fig. 1A, B, C). In the BrainMeta_cis_eQTL dataset, rs615552_AL359922.1 shows…
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Effect of gestational exposure to dim light at night on the behavior of rat dams and offspring
Animals
The parental generation comprised 16 female and 7 male Wistar rats, with initial weights of 243 ± 2 g for females and 334 ± 6 g for males (mean ± standard error of the mean, SEM). The animals were obtained from the…
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Cryptobenthic crab assemblages are more distinct across a 90 m depth gradient than 2500 km of shallow marine habitat in the Hawaiian archipelago
Graham, N. A. et al. Managing resilience to reverse phase shifts in coral reefs. Front. Ecol. Environ. 11, 541–548 (2013).
Norström, A. V., Nyström, M., Lokrantz, J. & Folke, C. Alternative…
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CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis
Human subjects research
This study does not involve sex-based analysis, and sex was not considered in the study design, since RA involves both. Therefore, for human participants, both male and female patients were included. All patients included…
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Biomechanical control of vascular morphogenesis by the surrounding stiffness
All genetic modification experiments in this study were approved by the Gene Recombination Experiment Committee established based on the University of Miyazaki internal regulations. All animal experiments using mice were carried out in accordance…
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Targeting oxidative stress and metal imbalance in cerebral ischemia: the neuroprotective role of sodium valproate
Surgery and treatments
For this purpose, a total of thirty-two male albino Wistar rats (220–230 g) were collected from the Elazig Veterinary Control Institute Animal Experiments Department. The animals were kept in controlled conditions…
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The value of prealbumin in predicting post hepatectomy liver failure for patients with hepatocellular carcinoma undergoing major hepatectomy
This study aims to explore the value of prealbumin and its comprehensive indicator, the prealbumin-Bilirubin (preALBI) score, in predicting PHLF. A total of 466 patients were included in the study and divided into two groups based on the cut-off…
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Agent-based simulation of cortical microtubule band movement in arabidopsis zygotes
The CMT band moves upward with a speed of 1.5 ± 1.2 μm/hour and a width of 5.2 ± 2.4 μm
To determine the mechanism by which the CMT band moves to maintain its position as the zygote expands, we first quantified the width and movement…
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Combatting virulent gut bacteria by inhibiting the biosynthesis of a two-component lanthipeptide toxin
General methods
All reagents used for chemical synthesis were purchased from Sigma Aldrich, Chem-Impex and CombiBlocks. N,N-Dimethylformamide (DMF) and dichloromethane (DCM) were dried over 3 Å molecular sieves before use. Chromatography was…
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