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Early-stage development of antibody–drug conjugates and complex bioconjugates requires the fast and reliable establishment of processes and analytical methods to support preclinical and first-in-human drug…
Category: 5. Biology
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XA-Novo: high-throughput mass spectrometry-based de novo sequencing technology for monoclonal antibodies and antibody mixtures
Lu, L. L., Suscovich, T. J., Fortune, S. M. & Alter, G. Beyond binding: antibody effector functions in infectious diseases. Nat. Rev. Immunol. 18, 46–61 (2018).
Oostindie, S. C., Lazar, G….
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Detection of known gene fusions in cancer cell lines using whole-genome bisulfite sequencing data
Liu, S. V., Nagasaka, M., Atz, J., Solca, F. & Müllauer, L. Oncogenic gene fusions in cancer: From biology to therapy. Signal Transduct. Target. Ther. 10, 111 (2025).
Belzen, I. A. E. M. van…
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Metabolic vulnerability in fusion-driven ependymoma
Fusions between the chromatin remodeller ZFTA and the NF-κB mediator RELA occur in approximately 80% of ependymomas, an aggressive form of central nervous system (CNS) tumour, where they function as potent oncogenic drivers. Currently, there are…
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Intracellular calcium handling dysfunction contributes to behavioural deficits leading to mortality of honey bees after acute contact exposure to the insecticide cyantraniliprole
IPBES. Summary for Policymakers of the Global Assessment Report on Biodiversity and Ecosystem Services. https://zenodo.org/records/3553579 (2019).
Jactel, H. et al. Insect decline: Immediate action is needed. C. R. Biol. 343, 267–293 (2020).
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BET inhibition disrupts the FOXM1-MYC axis to induce BRCAness and enhance PARP inhibitor response
Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434, 913–917 (2005).
Farmer, H. et al. Targeting the DNA repair defect…
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Development and physicochemical evaluation of nutritional drink using underutilized Caralluma tuberculata L.
Calderón-Martínez, F. E., González-Escobar, J. L., González-Laredo, R. F., Borrás-Enriquez, A. J., Aguilar-Zárate, P. & Veana, F. Potentialities from Neglected and Underutilized Species for Sustainable Fermented Beverages Production….
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Bringing magnetofluorescent proteins into the cell
Steel and colleagues report the development and application of magnetoresponsive fluorescent proteins in novel imaging contexts, including MRI of MFP-expressing cells.
Like many tools in modern biology, fluorescent proteins have developed from…
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The coming proteoform revolution
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The next scientific frontier likely to be tamed is the proteome — an important nexus for the many interacting ‘-omes’ such as the genome, transcriptome and metabolome. Proteoforms, defined as the precise…
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Discovery and engineering of bacterial P450s for C-14 hydroxylation in ent-kaurane diterpenoids
Liu, M., Wang, W.-G., Sun, H.-D. & Pu, J.-X. Diterpenoids from Isodon species: an update. Nat. Prod. Rep. 34, 1090–1140 (2017).
Sun, H.-D., Huang, S.-X. & Han, Q.-B. Diterpenoids from Isodon…
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