Hematopoietic stem cells (HSCs) in aged individuals become less functional in their regenerative potential and biased towards myeloid cell output with reduced lymphoid and erythroid cell production. In Nature Aging, Sun et al. investigate the…
Category: 5. Biology
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The influence of physical activity on the mental health of high school students: the chain mediating effects of social support and self-esteem
Lee, J., Goh, M. & Yeo, S. Mental health awareness of secondary schools students: Mediating roles of knowledge on mental health, knowledge on professional help, and attitude towards mental health. Heliyon.
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Effect of virtual walk in green or urban spaces on pain perception among healthy adults
Raja, S. N. et al. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain 161(9), 1976–1982. https://doi.org/10.1097/j.pain.0000000000001939 (2020).
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Spatial distribution of exotic lumbricid earthworm Octolasion tyrtaeum in endangered Taxus contorta stands across Northwest Himalayan moist temperate forests
Pandit, M. K., Sodhi, N. S., Koh, L. P., Bhaskar, A. & Brook, B. W. Unreported yet massive deforestation driving loss of endemic biodiversity in Indian Himalaya. Biodivers. Conserv. 16, 153–163. https://doi.org/10.1007/s10531-006-9038-5 (2007).
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Targeting CAFs | Nature Immunology
Cancer-associated fibroblasts (CAFs) support an immunosuppressive tumor microenvironment (TME), in part by the release of complement factors and the recruitment of myeloid-derived suppressor cells (MDSCs) into the tumor, but therapeutic targeting…
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Optimizing ethyl methanesulphonate for mutagenesis of selected tef [Eragrostis tef (Zucc.) Trotter] genotypes
Cultivars, EMS doses, durations and their interaction effects on agronomic traits
Combined analysis of variance showing the effect of EMS doses, duration and interaction effects on assessed parameters of the M1 generation of the founder cultivars…
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A Large-Scale Dataset of Pre-Treatment TCR Repertoires in Colorectal Cancer Patients
The T cell receptor (TCR) is a protein expressed on the surface of T cells that is critical in the detection of diverse antigens and in the initiation of immune responses. TCRs are composed of alpha (α) and beta (β), or gamma (γ) and delta…
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Why genomic diversity should not be framed by census alone
Efforts to increase diversity in genomics datasets often default to proportional representation based on global census figures1. This approach equates inclusion with demographic parity, overlooking the scientific and ethical dimensions of…
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Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers
This study complies with all relevant ethical regulations, as detailed below. A complete list of all antibodies, RNAi, CRISPR and RT-qPCR reagents is available in Supplementary Information.
Clinical specimens
Use of breast cancer samples was…
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545-Million-Year-Old Footprints Rewrite the Origin Story of Complex Life
New fossil evidence suggests the Cambrian explosion—long hailed as the dramatic birth of complex animal life—may not have been the sudden evolutionary event we thought. Researchers analyzing ancient trace fossils from 545 million years ago…
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