Neurodegenerative diseases caused by aberrant aggregation of the tau protein, encoded by the MAPT gene, include Alzheimer’s disease, frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP). These diseases are collectively called…
Category: 5. Biology
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Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits
Gregory, G.A. et al. Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study. Lancet Diabetes Endocrinol. https://doi.org/10.1016/s2213-8587(22)00218-2 (2022)
Arffman, M. et al. Long-term…
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Of rigor and outreach, and practicing what we teach
Aditi U. Gurkar is an associate professor at the Aging Institute of the University of Pittsburgh, studying the mechanisms of ageing. We reached out to Aditi to discuss her career, perspective on the cellular ageing field, outreach efforts, and…
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A Subphase-Labeled Mitotic Dataset for AI-powered Cell Division Analysis
Roux, L. et al. Mitosis detection in breast cancer histological images An ICPR 2012 contest. J Pathol Inform 4(1), 8 (2013).
Roux, L. et al. Mitos & atypia: Detection of mitosis and evaluation…
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A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication
Pierson, T. C. & Diamond, M. S. The continued threat of emerging flaviviruses. Nat. Microbiol 5, 796–812 (2020).
Neufeldt, C. J., Cortese, M., Acosta, E. G. & Bartenschlager, R. Rewiring…
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Natural genetic variation impacts complement inhibitory activity of PFam54 orthologs of Asian Borrelia bavariensis
Kurtenbach, K. et al. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nat. Rev. Microbiol. 4, 660–669 (2006).
Steere, A. C. et al. Lyme borreliosis. Nat. Rev. Dis….
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Generalists connect microbiomes | Nature Genetics
A long-standing challenge in microbiome science is to move beyond site-by-site catalogs toward a unified view of microbial community organization, and to quantify the routes by which mobile genetic elements cross ecological boundaries. To this…
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Structure of a pH-sensitive pentameric ligand-gated ion channel from the Sarcoptes scabies mite
Thompson, A. J., Lester, H. A. & Lummis, S. C. R. The structural basis of function in Cys-loop receptors. Q. Rev. Biophys. 43, 449–499 (2010).
Schnizler, K. et al. A novel chloride channel in…
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Bacteria-soil–plant linkages underlie the mosaic structure of the soil bacterial communities in near-natural stands of Białowieża Primeval Forest
FAO. Global Forest Resources Assessment 2020: Main report. Rome (2020). https://doi.org/10.4060/ca9825en
Li, F., Zi, H., Sonne, C. & Li, X. Microbiome sustains forest ecosystem functions across hierarchical scales. EEH 2, 24–31.
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Microglial cathepsin B is necessary for neuronal efferocytosis in zebrafish and mice during brain development
Colonna, M. & Butovsky, O. Microglia function in the central nervous system during health and neurodegeneration. Annu. Rev. Immunol. 35, 441–468 (2017).
Wu, Y., Dissing-Olesen, L., MacVicar,…
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