This study complies with all relevant ethical regulations, as detailed below. A complete list of all antibodies, RNAi, CRISPR and RT-qPCR reagents is available in Supplementary Information.
Clinical specimens
Use of breast cancer samples was…
Category: 5. Biology
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Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
Ethical statement
HUES66 was derived at Harvard University, where ethics approval was obtained prior to its registration with NIH under NIH Human Embryonic Stem Cell Registry; NIHhESC-10-0057. The New York Genome Center cannot speak to the consent…
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Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts
Experimental model and study participant details
Human participants
This project was approved by the Institutional Review Board of UT Southwestern Medical Center and complied with all relevant ethical regulations. Recruitment of human participants…
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A novel nanoparticle vaccine displaying multistage tuberculosis antigens confers protection in mice infected with H37Rv
Hosseinpoor, A. R. et al. Monitoring inequalities is a key part of the efforts to end AIDS, tuberculosis, and malaria. Lancet 399, 1208–1210 (2022).
Fernandes, G. F. S., Thompson, A. M.,…
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Evolution of antifungal resistance in the environment
Fisher, M. C. et al. Emerging fungal threats to animal, plant and ecosystem health. Nature 484, 186–194 (2012).
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Denning, D. W. Global incidence and mortality of severe…
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Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency
Waldman, A. D., Fritz, J. M. & Lenardo, M. J. Nat. Rev. Immunol. 20, 651–668 (2020).
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Schenkel, J. M. & Pauken, K. E. Nat. Rev. Immunol. 23, 807–823 (2023).
…
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Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels
The modeled architectures of LmOR35-Orco under various stoichiometric ratios
Due to the lack of experimental structures of locust odorant receptors, we evaluated the predicted models using AF3 modeling and homology modeling, respectively. We found…
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Returning home to navigate challenges and meet potential in Poland
Returning home to navigate challenges and meet potential in Poland
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A computational approach to mycolic acid biosynthesis disruption in mycobacterium tuberculosis via molluscan metabolites as KasA inhibitors
Molecular Docking analysis
To determine binding affinities, a library of 730 molluscan metabolites was docked to the prepared KasA protein structure. The docking results were evaluated based on binding affinity scores, and the top ten compounds…
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Author Correction: SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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