Researchers have uncovered a powerful genetic mechanism that may help explain how some species evolve with surprising speed. Certain sections of DNA, known as “flipped” segments, appear to help fish rapidly adapt to new environments and even…
Category: 5. Biology
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Study reveals molecular control of tooth root formation and growth
Tooth root development relies on precise coordination of cellular signals, yet the underlying mechanisms remain unclear. Researchers have uncovered how two proteins, Gli2 and Gli3, work together to control signaling and…
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How squid survived Earth’s biggest extinction and took over the oceans
Squid and cuttlefish are among the ocean’s most fascinating animals, known for their color-changing skin and jet-like movement. For decades, scientists have tried to understand how these unusual creatures evolved. Progress has been slow because…
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Purdue University accelerates rare disease drug discovery with the WELLJET dispenser stacker
Scientists at Purdue University are using the WELLJET dispenser stacker from INTEGRA Biosciences to increase the speed, consistency and scale of drug screening for rare and neglected parasitic diseases. Integrating automated liquid…
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A long-range enhancer at -52Kb drives expression of the COUP-TFII transcription factor in erythroid cells
Pereira, F. A., Qiu, Y., Zhou, G., Tsai, M. J. & Tsai, S. Y. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 13(8), 1037–1049 (1999).
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DNA assembly with Sidewinder via 3-way junctions
The emergence of protein structure foundation models and genomic large language models have expanded the capacity to design DNA sequences with desired biological functions, such as encoding specific proteins, functional RNAs, metabolic pathways,…
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Band-Aid for antibody production | Nature Immunology
Keratinocytes provide skin barrier functions, protecting tissues from microorganisms and environmental damage to maintain tissue integrity. However, whether keratinocytes also contribute to broader systemic immune responses has remained unclear….
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The genetic architecture of an allosteric hormone receptor
International Human Genome Sequencing Consortium et al. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001).
Venter, J. C. et al. The Sequence of the Human Genome….
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Wound-healing, anti-inflammatory, and antioxidant activities of β-glucan from red sea-mangroves-associated Candida tropicalis
Isolation of yeast
Five marine yeast isolates were obtained (Y1, Y2, Y3, Y4, Y5). S. cerevisiae was used as reference for β-glucan production. The colony morphology and cells shape are shown in Supplementary Fig. S8. Isolated yeasts have round…
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Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation
McLean MH, Murray GI, Stewart KN, Norrie G, Mayer C, Hold GL, et al. The inflammatory microenvironment in colorectal neoplasia. PLoS One. 2011;6:e15366.
Lasry A, Zinger A, Ben-Neriah Y….
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