Growing evidence indicates that colonic microbes can influence feeding behaviour, but a neural circuit capable of transducing microbial sensory signals such as microbe-associated molecular patterns (MAMPs) from the gut to the brain has not yet…
Category: 5. Biology
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Guanine is an inhibitor of c-jun terminal kinases
Cell cultures
All procedures were carried out under the UK Animals (Scientific Procedures) Act (1986) and approved by the University of Manchester Review Ethics Panel. PER2::LUC MEFs were prepare from heterozygous PER2::LUC embryos17 at day…
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The insulin signalling network | Nature Metabolism
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Fischer, E. H. & Krebs, E. G. Conversion of…
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ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC
Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J. & Der, C. J. Drugging the undruggable RAS: mission possible? Nat. Rev. Drug Discov. 13, 828–851 (2014).
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In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression
This pilot in vitro study explored how decompression-induced microbubble nucleation and acoustic softening contribute to flow instability and potential SFC in human blood. The experimental setup simulated pressure conditions relevant to DCS,…
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A blueprint for biomolecular condensation driven by bacterial microcompartment encapsulation peptides
Azaldegui, C. A., Vecchiarelli, A. G. & Biteen, J. S. The emergence of phase separation as an organizing principle in bacteria. Biophys. J. 120, 1123–1138 (2021).
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Melting KRAS resistance | Nature Chemical Biology
Hofmann, M. H., Gerlach, D., Misale, S., Petronczki, M. & Kraut, N. Cancer Discov. 12, 924–937 (2022).
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Zhao, Z., Mei, Y., Wang, Z. & He, W. Cancers…
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CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription
Ethics statement
Our research complies with all relevant ethical regulations of Fudan University. All animal experiments were performed in accordance with protocols approved by the Institutional Animal Care and Use Committee of Fudan University…
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