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Category: 5. Biology
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Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels
The modeled architectures of LmOR35-Orco under various stoichiometric ratios
Due to the lack of experimental structures of locust odorant receptors, we evaluated the predicted models using AF3 modeling and homology modeling, respectively. We found…
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Returning home to navigate challenges and meet potential in Poland
Returning home to navigate challenges and meet potential in Poland
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A computational approach to mycolic acid biosynthesis disruption in mycobacterium tuberculosis via molluscan metabolites as KasA inhibitors
Molecular Docking analysis
To determine binding affinities, a library of 730 molluscan metabolites was docked to the prepared KasA protein structure. The docking results were evaluated based on binding affinity scores, and the top ten compounds…
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Author Correction: SAMHD1-induced endosomal FAK signaling promotes human renal clear cell carcinoma metastasis by activating Rac1-mediated lamellipodia protrusion
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate…
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Regulation of kinesin-2 motility by its β-hairpin motif
Vale, R. D. The molecular motor toolbox for intracellular transport. Cell 112, 467–480 (2003).
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Wickstead, B., Gull, K. & Richards, T. A. Patterns of kinesin evolution…
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Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015).
García-García, M. J. in Animal Models of Human Birth Defects (ed. Liu, A.) 1–38 (Springer,…
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Increased breathlessness in post-COVID syndrome despite normal breathing patterns in a rebreathing challenge
The current study is part of the innovative training network ETUDE (Encompassing Training in fUnctional Disorders across Europe; https://etude-itn.eu/), ultimately aiming to improve the understanding of mechanisms, diagnosis, treatment and…
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Comprehensive identification of NRG1 fusions in 25,203 patients with solid tumors
The frequency of NRG1 fusions across solid tumor types
We collected next-generation sequencing (NGS) data from tumor samples from 25,203 patients across 15 types of solid tumors (Table 1). Among these patients, 49 patients with NRG1 fusions were…
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Intraepithelial T cells move from gut to breast to shape lactation
Intraepithelial T cells move from gut to breast to shape lactation
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