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Category: 5. Biology
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Carboxylation switch | Nature Immunology
Activation of mitochondrial antiviral signaling protein (MAVS) at the mitochondria membrane mediates both interferon (IFN) and apoptosis responses. In Science, Okazaki et al. show that carboxylation of MAVS enhances type I IFN responses and…
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Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development
The miR-200 family is required during early cardiac development
To determine if miR-200 is a key player in mammalian cardiac development, we profiled miR-200 family expression from embryonic mouse whole heart RNA. Transcripts encoding the miR-200…
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Intermittent fasting and a no-sugar diet for Long COVID symptoms: a randomized crossover trial
Al-Aly, Z. et al. Long COVID science, research and policy. Nat. Med. 30, 2148–2164 (2024).
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Peluso, M. J. & Deeks, S. G. Mechanisms of long COVID and the path toward therapeutics….
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Enhancing adoptive cell therapy: future strategies for immune cell radioprotection in neuro-oncology
Adoptive cell therapy (ACT) including chimeric antigen receptor (CAR) T-cell therapy has shown promising early signals of activity in treating select patients with brain tumors1. ACT is a type of immunotherapy that uses a patient’s own immune…
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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights
Patient characteristics
A total of 186 patients with DLC were screened from March 2022 to March 2024. The study comprised two stages (Phases Ia and Ib), as shown in Fig. 1. Phase Ia enrolled 15 patients who received MSC infusions following a…
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Cultivar specific nitrogen and potassium recommendations optimize yield and quality attributes in sugar beet
Variation in yield and quality traits among sugar beet cultivars
The performance of five sugar beet cultivars (Indira, Carma, Mallak, Melodia, and Shantala) was evaluated across ten yield and quality traits (Fig. 1). Significant variations were…
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Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis
Hampel, H. et al. The amyloid-β pathway in Alzheimer’s disease. Mol. Psychiatry 26, 5481–5503 (2021).
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Murphy, M. P. & LeVine, H. 3rd…
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Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2
ZHX2 is overexpressed in DLBCL and promotes DLBCL proliferation
To clarify the characteristics of ZHX2 in DLBCL, immunohistochemistry (IHC) showed elevated expression in DLBCL (n = 60) compared to normal tonsils (n = 30; mean optical density…
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SOuLMuSiC, a novel tool for predicting the impact of mutations on protein solubility
Prediction performances
We tested the prediction performance of SOuLMuSiC on different datasets. We started with the training set \(\mathcal {D}_{Sol}\), and evaluated the performance in leave-one-out cross-validation at protein level. The…
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