Transcriptome sequencing and gene expression analysis
This study performed 150 bp paired-end transcriptome sequencing on roots, stems, leaves, and fruits (ovaries) of P. somniferum across developmental stages, generating 2.32 billion raw reads….
Category: 5. Biology
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DynaTag for efficient mapping of transcription factors in low-input samples and at single-cell resolution
Ethical statement
The patient sample S0273026 was collected under approved protocols of the institutional review board (IRB, ID: 19-1164) of the University of Cologne and provided written informed consent to share potentially identifying…
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Myeloid cells in chronic liver inflammation
Marcellin P, Kutala BK. Liver diseases: a major, neglected global public health problem requiring urgent actions and large-scale screening. Liver Int. 2018;38:2–6.
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Younossi ZM, Wong…
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Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study
Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357–81.
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Di Martino A, Scheres…
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SNP rs615552 and lncRNA CDKN2B-AS1 influence brain cancer pathogenesis through multi-omic mechanisms
Multi-omics colocalization analysis reveals key genetic variants in brain cancer
eQTL analysis indicates that CDKN2A, CDKN2B, and CDKN2B-AS1 co-locate with brain cancer(Fig. 1A, B, C). In the BrainMeta_cis_eQTL dataset, rs615552_AL359922.1 shows…
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Effect of gestational exposure to dim light at night on the behavior of rat dams and offspring
Animals
The parental generation comprised 16 female and 7 male Wistar rats, with initial weights of 243 ± 2 g for females and 334 ± 6 g for males (mean ± standard error of the mean, SEM). The animals were obtained from the…
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Cryptobenthic crab assemblages are more distinct across a 90 m depth gradient than 2500 km of shallow marine habitat in the Hawaiian archipelago
Graham, N. A. et al. Managing resilience to reverse phase shifts in coral reefs. Front. Ecol. Environ. 11, 541–548 (2013).
Norström, A. V., Nyström, M., Lokrantz, J. & Folke, C. Alternative…
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CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis
Human subjects research
This study does not involve sex-based analysis, and sex was not considered in the study design, since RA involves both. Therefore, for human participants, both male and female patients were included. All patients included…
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Biomechanical control of vascular morphogenesis by the surrounding stiffness
All genetic modification experiments in this study were approved by the Gene Recombination Experiment Committee established based on the University of Miyazaki internal regulations. All animal experiments using mice were carried out in accordance…
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Targeting oxidative stress and metal imbalance in cerebral ischemia: the neuroprotective role of sodium valproate
Surgery and treatments
For this purpose, a total of thirty-two male albino Wistar rats (220–230 g) were collected from the Elazig Veterinary Control Institute Animal Experiments Department. The animals were kept in controlled conditions…
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