In daily life, people often need to estimate unknown events (e.g., the number of people attending a conference or the price of a car). How can people make accurate estimates for these types of questions? One promising approach is that of ‘the…
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First-line tislelizumab and ociperlimab combined with gemcitabine and cisplatin in advanced biliary tract cancer (ZSAB-TOP): a multicenter, single-arm, phase 2 study
To our knowledge, ZSAB-TOP is the first study evaluating the efficacy and safety of adding a TIGIT inhibitor to the standard combination of a PD-1 inhibitor and GemCis in advanced BTC. Our results demonstrated that the combination of ociperlimab,…
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Novel PLA-Henna composite for sustainable tertiary enhanced oil recovery
Feng, G. et al. Novel facile nonaqueous precipitation in-situ synthesis of mullite whisker skeleton porous materials. Ceram. Int. 44(18), 22904–22910 (2018).
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Feng, G. et al….
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Extended native gate sets to unlock the performance of quantum processors
Extended native gate sets to unlock the performance of quantum processors
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Solving the coupled Gerdjikov–Ivanov equation via Riemann–Hilbert approach on the half line
The expressions and notations employed within this research
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The Pauli matrix is marked as \(\theta _{3}\), \(\theta _{3}=\left( \begin{array}{cc}1 & 0 \\ 0 & -1 \\ \end{array}\right)\), \(\theta _{-}=\left(…
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The effect of age-related sensorimotor changes on step-down strategy: a predictive simulation study
In a nutshell, we performed predictive simulations that were built upon the established reflex-based walking model by Geyer and Herr14. From this model, we created five models reflecting the neuromuscular changes found in older adults by reducing…
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The Escherichia coli replication initiator DnaA is titrated on the chromosome
Willis, L. & Huang, K. C. Sizing up the bacterial cell cycle. Nat. Rev. Microbiol. 15, 606–620 (2017).
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Reyes-Lamothe, R. & Sherratt, D. J. The bacterial cell cycle,…
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Association between the respiratory severity score and extubation success in severe bronchopulmonary dysplasia
Horbar JD, Carpenter JH, Badger GJ, Kenny MJ, Soll RF, Morrow KA, et al. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics. 2012;129:1019–26.
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Structural relaxation of ferroelectric phase in hard sodium lithium niobate solid solutions studied by solid-state NMR
Figure 1 displays the spectra of 23Na MAS NMR for (a) the LNNx system with 0.12 < x < 0.18, (b) the LNN18 aged for 8 h at a temperature T ϵ [500,800] °C and (c) the LNN18 aged for 24 h at 500 °C and at 600 °C for a time t ϵ…
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Fencing the genome: ubiquitin signaling restricts heterochromatin spread
In a recent study published in Science, Tiebang Kang and his colleagues1 identify ASB7 as a key negative regulator of heterochromatin maintenance through targeted degradation of the H3K9me3…
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