Prime editing guide RNA design and plasmid construction
PrimeDesign (https://drugthatgene.pinellolab.partners.org/)43 and pegFinder (http://pegfinder.sidichenlab.org/)44 were used to design epegRNA and nicking sgRNA candidates. The designed…
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Subaqueous evidence of the last glacial maximum and its termination in southern Patagonia
Denton, G. H. et al. The last glacial termination. Science 328, 1652–1656 (2010).
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Denton, G. H., Broecker, W. S. & Alley, R. B. The mystery interval 17.5 to…
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Implicit neural representation for fast 4D computed tomography of multiphase flow in porous media
Withers, P. et al. X-ray computed tomography. Nat. Rev. Methods Prim. 1, 1–17 (2021).
Cnudde, V. & Boone, M. High-resolution X-ray computed tomography in geosciences: a review of the current…
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Endogenous OptoRhoGEFs reveal biophysical principles of epithelial tissue furrowing
Development and characterization of endogenous OptoRhoGEFs
We engineered an optogenetic system into Drosophila melanogaster based on the LOV2-derived iLID/SspB molecular switch, in which light exposure causes an iLID conformational change that…
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The wood microbiome inside living trees
The wood of living trees forms the largest reservoir of biomass on Earth, yet little is known about the microbial communities inside trees. Now, Arnold et al. present the microbiome inhabiting the wood of living trees. Using a new type of…
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Ready-made bodily sensations | Scientific Reports
Developing a new researchers-friendly BSM visualisation tool and analysis approach
Leveraging methodologies by Schino et al.26 Ruta and Schino46 and Nummenmaa et al.19 we developed a custom open-access R script to visualise BSMs, offering a…
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Long-term survival in patients with Philadelphia-chromosome-positive acute lymphoblastic leukemia who relapse after allogeneic hematopoietic stem cell transplantation: a single-center experience
Giebel S, Czyz A, Ottmann O, Baron F, Brissot E, Ciceri F, et al. Use of tyrosine kinase inhibitors to prevent relapse after allogeneic hematopoietic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic…
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Challenges to the cosmological constant model following results from the Dark Energy Survey
Lorentz, H. A., Einstein, A., Minkowski, H. & Weyl, H. The Principle of Relativity: A Collection of Original Memoirs on the Special and General Theory of Relativity (Meuthen & Co., 1923).
Percival, W. J. et al. The 2df Galaxy Redshift Survey: the…
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Performance evaluation and multi-objective optimization of EDM parameters for Ti6Al4V using different tool electrodes
The experimental values obtained for MRR, TWR, SR, and DD responses by following Taguchi’s approach have been represented in Table 4 for all the tool electrodes of copper, brass, and graphite.
Table 4 Results of measured responses following… Continue Reading