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  • Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47

    Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47

    CD47 mRNA 3′ UTR length affects its protein localization

    Previous studies have demonstrated that global alterations in mRNA polyadenylation, resulting from the utilization of different PASs, play a crucial role in post-transcriptional gene…

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  • Flow and heat transfer characteristics of 3D printed sheet and solid triply periodic minimal surfaces porous structures

    Flow and heat transfer characteristics of 3D printed sheet and solid triply periodic minimal surfaces porous structures

    Mathematical design of TPMS structures

    Primitive, Gyroid and Diamond surfaces can be described by the following equations given in Table 1. The function f(x, y, z) is and iso-surface evaluated at an iso-value C. The space is separated by the TPMS…

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  • H3K27me3-mediated epigenetic regulation of TET1 in the eutopic endometrium of women with endometriosis and infertility

    H3K27me3-mediated epigenetic regulation of TET1 in the eutopic endometrium of women with endometriosis and infertility

    Our main finding was no significant H3K27me3 differences in any TET1 promoter region between endometriosis and controls, regardless of ChIP efficiency. This contrasts with our hypothesis, suggesting a more complex H3K27me3–TET1 relationship in…

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  • F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

    F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets

    A list of reagents and antibodies can be found in Supplementary Data 1.

    Animals

    This project was approved by the local ethical committee CEEA26 and the French government under the number APAFIS#25086-2020032312267714. Mical1fl/fl mice were kindly…

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  • Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke

    Microglia are prominent producers of inflammatory cytokines during the hyperacute phase of ischemic stroke

  • DiSabato, D. J., Quan, N. & Godbout, J. P. Neuroinflammation: the devil is in the details. J. Neurochem 139, 136–153 (2016).

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  • Gauberti, M. et al….

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  • Time series analysis of ex-vivo ischemia-reperfused heart using Q-space imaging

    Time series analysis of ex-vivo ischemia-reperfused heart using Q-space imaging

    QSI was sensitive in delineating MI lesions

    In this study, a strong correlation was found between the regions exhibiting alterations in QSI signals following IR and those exhibiting histological changes via Masson’s trichrome staining, both in…

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  • Efficacy of remimazolam in preventing postoperative nausea and vomiting: a systematic review and meta-analysis

    Efficacy of remimazolam in preventing postoperative nausea and vomiting: a systematic review and meta-analysis

    Literature search

    An initial search yielded 319 articles from the Medline, Embase, and Cochrane Library databases. After removing 68 duplicates, the titles and abstracts of the remaining 251 unique studies were reviewed. Of these studies, 63…

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  • Diabetic retinopathy classification using a multi-attention residual refinement architecture

    Diabetic retinopathy classification using a multi-attention residual refinement architecture

    This section focuses on the method of the proposed model. We first introduced the class-specific residual attention module and then proposed a multi-attention mechanism to improve the ability of small object detection (lesions detection). Then,…

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