In this study, images including axial brain slices and T1-weighted structural MRI data were used to diagnose Alzheimer’s disease. EfficientNetB2, InceptionV3, Regnetx006 and the proposed new models were employed on 224 × 224 rescaled MRI…
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Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy
The comprehensive workflow of the present study is delineated in Fig. 1. This study received approval from the Institutional Review Board of the Fifth Affiliated Hospital of Sun Yat-sen University (Ethical approval number: 2024-S-11), and…
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Flow and heat transfer characteristics of 3D printed sheet and solid triply periodic minimal surfaces porous structures
Mathematical design of TPMS structures
Primitive, Gyroid and Diamond surfaces can be described by the following equations given in Table 1. The function f(x, y, z) is and iso-surface evaluated at an iso-value C. The space is separated by the TPMS…
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Harnessing electroacupuncture: a promising strategy against sleep deprivation-exacerbated post-cardiac arrest brain injury
Ramireddy, A. S. S. & Chugh Do peak times exist for sudden cardiac arrest? Trends Cardiovasc. Med. 31 (3), 172–176 (2021).
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Perkins, G. D. et al. Brain injury after cardiac…
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Genome-wide CRISPR screen for human factors involved in alternative polyadenylation based on differential localization of CD47
CD47 mRNA 3′ UTR length affects its protein localization
Previous studies have demonstrated that global alterations in mRNA polyadenylation, resulting from the utilization of different PASs, play a crucial role in post-transcriptional gene…
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Explainable ML modeling of saltwater intrusion control with underground barriers in coastal sloping aquifers
Figure 1 outlines the methodology for predicting L/La in coastal sloping aquifers with underground barriers using Bayesian-optimized gradient boosting models. A dataset of 456 numerical samples, containing key hydraulic parameters as inputs and…
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Self-splicing RNA circularization facilitated by intact group I and II introns
PIE can begin with the second step of the transesterification process
Group I introns, which are self-splicing ribozymes, enable RNA splicing without protein assistance, functioning through a two-step transesterification reaction that requires…
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F-actin disassembly by the oxidoreductase MICAL1 promotes mechano-dependent VWF-GPIbα interaction in platelets
A list of reagents and antibodies can be found in Supplementary Data 1.
Animals
This project was approved by the local ethical committee CEEA26 and the French government under the number APAFIS#25086-2020032312267714. Mical1fl/fl mice were kindly…
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Multimodal machine learning for risk-stratified bundled payments in spinal surgery
Spine surgery is a major contributor to healthcare costs in the United States1, with its high volume and complexity contributing to an annual economic burden exceeding $24.3 billion2,3. Despite the introduction of VBC frameworks such as BPCI and…
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AI enhanced model predictive control for optimizing LPG recovery through integrated computational modeling design of experiments and multivariate regression
Steady-state process simulation
The steady-state simulation of the debutanizer unit, as illustrated in Fig. 5, established a baseline for assessing operational performance. Key process variables, including temperature, pressure, and composition…
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