Reversed-phase high-performance liquid chromatography
Reversed-phase high performance liquid chromatography (RP-HPLC) was performed on an Agilent 1260 HPLC equipped with quaternary pump, diode array (DAD) and fluorescence detection. SARS-CoV-2…
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Pathways linking BMI trajectories and mental health in an adult population-based cohort: role of emotional eating and body dissatisfaction
Phelps NH, Singleton RK, Zhou B, Heap RA, Mishra A, Bennett JE, et al. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults….
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Evaluation of climate indices related to water resources in Iran over the past 3 decades
Precipitation indices
Number of days with heavy precipitation (R20mm)
The number of days with heavy precipitation (> 20 mm/day) was analyzed across study cities during 1992–2022 (Fig. 2, Tables S1–S5). Trend analysis (Fig. 4, Table S61)…
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Lithium isotopic composition of the carbonate type salt lake in Tibet and its implication for origin and hydrological processes
Kesler, S. E. et al. Global lithium resources: relative importance of pegmatite, Brine and other deposits. Ore Geol. Rev. 48, 55–69. https://doi.org/10.1016/j.oregeorev.2012.05.006 (2012).
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How well do different chatbots respond to multiple myeloma treatment guidelines?
Recent publications in Leukemia offer further affirmation that daratumumab is a cornerstone of first-line therapy for transplant-ineligible patients with newly diagnosed multiple myeloma (NDMM) [1, 2]. These articles are a subgroup analysis and…
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Development and validation of an LC–MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma
Chemical reagent
LXT-101 (purity: 95%, LOT: 050503) and 127I-LXT-101 (IS, purity: ≥ 99%, LOT: 050307) were obtained from Beijing Institute of Pharmacology and Toxicology (Beijing, China). Methanol, acetonitrile and formic acid, which were of…
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Neural encoding of handwriting in the human motor cortex
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This is a summary of: Qi, Y. et al. Human motor cortex encodes complex handwriting through a sequence of…
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Molecular insights into the overall architecture of human rixosome
Structure of the human PELP1-WDR18-TEX10 complex
To prepare samples of the human PELP1-WDR18-TEX10 complex, we used insect cells to co-express PELP1-WDR18 and express TEX10 separately. PELP1 covered only the Rix1 domain (residues 1-642, Fig. 1a),…
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SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma
Cell culture
Human malignant glioblastoma multiforme U251 and U87 cell lines were grown in high-glucose Dulbecco’s Modified Eagle Medium (DMEM, SolarBio, #11995) containing 4 mM l-glutamine, and supplemented with 10% fetal bovine serum (FBS)….
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MRI-based digital twins to improve treatment response of breast cancer by optimizing neoadjuvant chemotherapy regimens
Patient population
Treatment-naïve stage I-III TNBC patients were enrolled in the prospective clinical trial, “ARTEMIS: A Robust TNBC Evaluation FraMework to Improve Survival” (ClinicalTrials.gov Identifier: NCT02276443, registered on October…
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