Treg instability drives anti–PD-1 + anti–LAG-3 treatment efficacy and is associated with therapeutic response in patients with metastatic melanoma.
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The response to anti–PD-1 and anti–LAG-3 checkpoint blockade is associated with regulatory T cell reprogramming | Science Translational Medicine
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Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay | Science Translational Medicine
A low complexity, portable lab-in-tube tuberculosis assay for resource-limited areas analyzes blood, saliva, and sputum with a handheld device.
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Succinate-loaded tumor cell–derived microparticles reprogram tumor-associated macrophage metabolism | Science Translational Medicine
Engineered tumor cell–derived microparticles induce histone and enzyme succinylation in tumor-associated macrophages to promote an M1-like phenotype.
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Collagen V regulates renal function after kidney injury and can be pharmacologically targeted to enhance kidney repair in mice | Science Translational Medicine
Collagen V regulates renal fibrosis and can be targeted with precision medicine approaches.
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Spatial genomics: Mapping the landscape of fibrosis | Science Translational Medicine
Spatial genomics unlocks insights into the pathobiology of multiorgan fibrosis across time and space.
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Erratum for the Research Article “A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection” by L.-L. Wang et al. | Science Translational Medicine
Figure S8 of the Research Article “A gut Eggerthella lenta–derived metabolite impairs neutrophil function to aggravate bacterial lung infection” by L.-L. Wang et al. depicts P. aeruginosa–induced lung injuries in mice gavaged with either…
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What Makes the Ocean Glow? Inside the Strange, 400-Year Mystery of “Milky Seas”
For centuries, sailors have reported the eerie glow of “milky seas” — vast areas of ocean that shine at night like a soft green-white light. Scientists now believe this rare phenomenon is caused by bioluminescent bacteria, but much remains…
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Mood Swings During Sickness Are Caused by Complex Brain-Immune Crosstalk
Feeling sluggish, depressed, anxious, and having trouble concentrating while being sick might not just be due to physical weakness. Extensive reports from health professionals have pointed out that these symptoms, labeled “sickness behavior,” are…
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Startups are preparing for the launch of space-based solar power
Electrical engineer Ed Tate was skeptical of proposals for space-based solar power when he initially heard about the concept seven years ago.
“My first reaction was, ‘That really sounds like science fiction. I don’t think that will…
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Construction Economics for April 14, 2025, 2025
In today’s fast-paced, heavy civil construction industry, the ability to collect, analyze, and act on data is more critical than ever. Join us for an exclusive webinar exploring how contractors can leverage data, reporting, and emerging AI…
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