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  • Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory

    Development of a simplified smell test to identify Parkinson’s disease using multiple cohorts, machine learning and item response theory

    Comparing different smell tests to classify typical Parkinson’s disease

    We used de-identified data from three observational, retrospective, case-control studies: the De Novo Parkinson disease study (DeNoPa)23; the Ottawa (PREDIGT) Trial; and the…

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  • Benchmark evaluation of DeepSeek large language models in clinical decision-making

    Large Language Models (LLMs) are increasingly transforming medical applications. However, proprietary models such as GPT-4o face significant barriers to clinical adoption because they cannot be deployed on site within healthcare institutions,…

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  • Exploring climate nudge attitudes—the significance of perceived climate change knowledge, science trust, and media trust

    Exploring climate nudge attitudes—the significance of perceived climate change knowledge, science trust, and media trust

    Since the concept of nudging gained prominence in 2008, numerous studies have explored public attitudes toward it (e.g., Sunstein et al., 2018; Sunstein & Reisch, 2018; Almqvist and Andersson, 2021). Overall, people’s attitudes toward nudging…

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  • The impact of eyeliner usage on dry eye symptoms

    The impact of eyeliner usage on dry eye symptoms

    In this questionnaire survey, it was observed that individuals who regularly use eyeliner tend to exhibit higher OSDI scores, suggesting a potential link between the use of this cosmetic product and the health of the ocular surface. This finding…

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  • GaN HEMTs-based compact power factor corrected 96.1% peak efficiency LED driver with gate assisted circuit

    GaN HEMTs-based compact power factor corrected 96.1% peak efficiency LED driver with gate assisted circuit

    1. (A)

      BCM boost cell.

    Figure 4 shows that peak voltage reaches across Lb at time t3 during one complete operation period….

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  • Towards a genetic obesity risk score in a single-center study of children and adolescents with obesity

    Towards a genetic obesity risk score in a single-center study of children and adolescents with obesity

    In this Italian single-center cohort of 50 children and adolescents living with obesity, we detected thirty-four genetic variants in approximately half of the patients. A total of six variants (12%) were classified as pathogenic/likely…

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  • Optimal timing of cancer treatments: a call for emerging evidence from clinical trials and real-world studies

    Optimal timing of cancer treatments: a call for emerging evidence from clinical trials and real-world studies

    With the increasing complexity of approaches to cancer treatment, especially biomarker-driven therapies, the impact of treatment timing on prognosis becomes a pressing question to answer. Despite randomised clinical trials (RCTs) being the gold…

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  • Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis

    Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis

    Understanding the causes of treatment failure is crucial for the management of axial spondyloarthritis

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