Baseline characteristics
To characterize the baseline features of the study population, our analysis included 10,961 participants with comprehensive baseline characteristics, as shown in Table 1. The cohort exhibited a balanced gender…
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Hybrid Kerr-electro-optic frequency combs on thin-film lithium niobate
Device fabrication and parameters
DKS devices are fabricated on a commercial Z-cut thin-film lithium niobate (Z-TFLN) on-insulator wafer (NANOLN). The initial film thickness is 600 nm of Z-TFLN on top of 2 μm thermal oxide and 0.525 mm…
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Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study
Genetic variant selection
After clumping, we identified 374 SNPs for TC, 415 for HDL-C, 313 for LDL-C and 370 for TG (Supplementary table S4). Genetically proxied levels of lipids were significantly associated with CAD33,34 (Supplementary table…
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Enhancing the optoelectronic and mechanical response of MgXCl3 (X = Rb, Cl) for advance energy conversion applications
In this portion, we will provide a comprehensive overview of the structural, elastic, electronic, and optical properties of Mg-based perovskites, highlighting key findings and insights into their behavior and potential applications MgXCl3…
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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Plasmacytoid DCs convert into cDC2s on activation
We hypothesized that single-cell multiomics would allow us to track the fate of individual pDCs during activation. To establish a reference framework, we first generated a panDC map capturing the…
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Numerical and Mechanical Analysis of Direct Wafer Bonding Considering Non-Uniform Impurity Particle Distributions
Direct wafer bonding is defined as a bonding procedure involving two clean, highly polished wafers, with no intermediate layer used1. Once the two polished wafers have undergone cleaning and surface activation, they are brought into contact and…
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Machine learning-assisted quantitative metabolomics of West African patients with advanced breast cancer
We present a blood metabolic profile of breast cancer patients at the time of diagnosis and prior to any treatment, obtained using targeted quantitative metabolomics and combined statistical and machine learning approaches. To our knowledge, this…
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Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates
Cell culture
HEK293T (American Type Culture Collection (ATCC), CRL-11268) were cultured as recommended by the ATCC. Cell lines tested negative for Mycoplasma and were authenticated by the suppliers.
Modeling of gene-editing outcomes
The inDelphi…
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Application of machine learning and temporal response function modeling of EEG data for differential diagnosis in primary progressive aphasia
Participants
Participants included 10 healthy, age-, education-, and hearing-matched control participants, 10 individuals with svPPA, 10 individuals with nfvPPA, and 10 individuals with lvPPA (Table 1; note that control participants and…
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