Genetic variant selection
After clumping, we identified 374 SNPs for TC, 415 for HDL-C, 313 for LDL-C and 370 for TG (Supplementary table S4). Genetically proxied levels of lipids were significantly associated with CAD33,34 (Supplementary table…
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Research status of roof water and sand bursting disaster in thick bedrock stope of coal seam
Geological conditions and occurrence of the accident
Zhaojin Coal Mine is located in the Xunyao Mining Area, Huanglong Coalfield, Shaanxi Province, China, and mainly mines No.4− 2 coal seams of the Jurassic System. The geological structure of…
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To explore the association between the neutrophil percentage to albumin ratio and low bone mineral density/osteoporosis based on NHANES 2011–2018
Baseline characteristics
To characterize the baseline features of the study population, our analysis included 10,961 participants with comprehensive baseline characteristics, as shown in Table 1. The cohort exhibited a balanced gender…
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Numerical and Mechanical Analysis of Direct Wafer Bonding Considering Non-Uniform Impurity Particle Distributions
Direct wafer bonding is defined as a bonding procedure involving two clean, highly polished wafers, with no intermediate layer used1. Once the two polished wafers have undergone cleaning and surface activation, they are brought into contact and…
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Machine learning-assisted quantitative metabolomics of West African patients with advanced breast cancer
We present a blood metabolic profile of breast cancer patients at the time of diagnosis and prior to any treatment, obtained using targeted quantitative metabolomics and combined statistical and machine learning approaches. To our knowledge, this…
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Pulse pressure after thrombectomy predicts functional outcomes and mortality in acute ischemic stroke with large artery occlusion
Study design and populations
This retrospective study analyzed consecutive AIS patients with LVO who underwent EVT between March 2016 and August 2023 at the Stroke Center of the Second Affiliated Hospital, Zhejiang University (Fig. 1). As a…
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Adaptive differential current relay based on form/ripple factors for busbar current signals
Basic concept
It is known that any fault current signal encompasses AC with/without DC components. The shape of the current signal is measured by the form factor, and the ripple content in the signal is measured by the ripple factor36,37. Both…
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TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells
Plasmacytoid DCs convert into cDC2s on activation
We hypothesized that single-cell multiomics would allow us to track the fate of individual pDCs during activation. To establish a reference framework, we first generated a panDC map capturing the…
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Development of in-house software to process real-time cine magnetic resonance images acquired during 1.5 T MR-guided radiation therapy
Acquisition of 2D cine MR images using the 1.5 T MR-linac
In contrast to conventional radiotherapy, the MRgRT workflow involves acquiring pre-treatment MR images, which are registered with a reference image set. This process allows for the…
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25 nm-Feature, 104-aspect-ratio, 10 mm2-area single-pulsed laser nanolithography
Superiority and versatility of the WEALTH technique
We leverage the spherical aberration enhancement effect to redistribute the light field energy, stretching the Rayleigh length of the focus beyond 100 µm (Supplementary Fig. #1), and…
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