This section offers a comprehensive overview of our proposed approach, named AttendFew. It comprises several key steps, such as Instance Attentive Encoding, Attention-guided Prototype Model, and Aggregated Class Matching. Figure 2 illustrates…
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Association between sleep duration and hypertension risk in patients with obstructive sleep apnea
Baseline characteristics
After excluding participants with an AHI < 15 events/h (n = 3230), a total of 2574 participants were included in the analysis examining the association between sleep duration and hypertension prevalence. For the…
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Chemigenetic kinase biosensors illuminate cell signaling networks
Frei, M. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02642-8 (2025).
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Wang, L., Hiblot, J., Popp, C., Xue, L. & Johnsson, K. Angew. Chem. Int. Edn Engl. 59,…
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Electric vehicle integrated tidal-solar-wind-hydro-thermal systems for strengthing the microgrid and environment sustainability
Electric vehicles (EVs) do not rely on fossil fuels to power their batteries, instead using electricity, offering a significant promise for environmental and economic benefits by reducing fossil fuel dependency. EVs play a vital role in…
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DNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages
Generation of PTEC-specific I-PpoI-expressing mice
R26R-I-PpoI knock-in mice (accession no. CDB0059E; https://large.riken.jp/distribution/mutant-list.html) were generated via CRISPR/Cas9-mediated knock-in in zygotes as previously described77. First, we…
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Breaking data silos in drug discovery with federated learning
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Design of PROTACs utilizing the E3 ligase GID4 for targeted protein degradation
Bekes, M., Langley, D. R. & Crews, C. M. PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. https://doi.org/10.1038/s41573-021-00371-6 (2022).
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Multistability bifurcation analysis and transmission pathways for the dynamics of the infectious disease-cholera model with microbial expansion inducing the Allee effect in terms of Guassian noise and crossover effects
Poor sanitation, insufficient hygiene and a lack of water treatment are the main causes of cholera outbreaks3. We may address these environmental concerns more effectively by including noise in our deterministic model (2.11), then the stochastic…
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Dissecting cross-population polygenic heterogeneity across respiratory and cardiometabolic diseases
East Asian samples in BioBank Japan
EAS population analysis included samples from BBJ, a hospital-based registry with multi-omics data from genotypes to multitudes of phenotypes. All the participants in BBJ provided written, informed consent…
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