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  • Integrative Mendelian randomization and multi-omics analysis identifies anti-allergic drug targets associated with cardiovascular disease risk

    Integrative Mendelian randomization and multi-omics analysis identifies anti-allergic drug targets associated with cardiovascular disease risk

    A comprehensive MR analysis was performed on 139 eQTLs linked to anti-allergic drugs within discovery cohorts of 122,733 CAD patients, 68,157 HF patients, 395,795 MI patients, and 60,620 AF patients. Subsequently, these eQTLs were validated in…

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  • A sphingolipid-derived paclitaxel nanovesicle enhances efficacy of combination therapies in triple-negative breast cancer and pancreatic cancer

    A sphingolipid-derived paclitaxel nanovesicle enhances efficacy of combination therapies in triple-negative breast cancer and pancreatic cancer

    Chemical synthesis

    The detailed step-by-step approaches of chemical synthesis have been deposited in the protocols.io repository27.

    Ethical statement

    All mice studies were approved (protocol no. 19-545) by University of Arizona (UArizona)…

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  • Photocatalytic and theoretical study of CoS nanoparticles for sustainable dye removal from wastewater

    Photocatalytic and theoretical study of CoS nanoparticles for sustainable dye removal from wastewater

    Fig. 1

    (a) XRD of CoS nanoparticle, (b) N2 adsorption/desorption isotherm of CoS nanoparticle, (inset: pore size distribution).

    Scheme 1 represents the simple precipitation approach that was used to develop the CoS nanocomposite, which included…

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  • Optimization of dynamic incentive strategies for public transportation based on reinforcement learning and network synergy effect

    Optimization of dynamic incentive strategies for public transportation based on reinforcement learning and network synergy effect

    Based on the research gaps revealed by the literature review, this study proposed the Dynamic Incentive Strategy-Heterogeneous Response Collaborative Model (DIS-HARM) , which integrated the reinforcement learning framework, heterogeneous user…

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  • The impact of sports event brand experience on spectator loyalty: mediating roles of attitude and subjective norms

    The impact of sports event brand experience on spectator loyalty: mediating roles of attitude and subjective norms

  • Pine, B. J. & Gilmore, J. H. The Experience Economy: Competing for Customer Time, Attention, and Money (Harvard Business Review, 2021).

  • Winell, E., Nilsson, J. & Lundberg, E. Customer engagement behaviors on physical and virtual engagement…

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  • Solving the coupled Gerdjikov–Ivanov equation via Riemann–Hilbert approach on the half line

    Solving the coupled Gerdjikov–Ivanov equation via Riemann–Hilbert approach on the half line

    The expressions and notations employed within this research

    • The Pauli matrix is marked as \(\theta _{3}\), \(\theta _{3}=\left( \begin{array}{cc}1 & 0 \\ 0 & -1 \\ \end{array}\right)\), \(\theta _{-}=\left(…

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  • Polygenic risk score as a tool to predict gestational weight gain and gestational diabetes among pregnant women in Taiwan

    Polygenic risk score as a tool to predict gestational weight gain and gestational diabetes among pregnant women in Taiwan

  • Li G, Wei T, Ni W, Zhang A, Zhang J, Xing Y, et al. Incidence and risk factors of gestational diabetes mellitus: a prospective cohort Study in Qingdao, China. Front Endocrinol. 2020;11:636.

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  • The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response

    The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response

    Developing pan-cancer markers: a universal methylation identifier for 36 distinct cancers

    We employed a method detailed in our previous study20, to identify CpG sites unmethylated in normal tissues and consistently methylated in tumors. This…

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