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  • A streamlined base editor engineering strategy to reduce bystander editing

    A streamlined base editor engineering strategy to reduce bystander editing

    Development of a structure-guided protein re-engineering strategy to narrow the base editing window

    By analyzing the available structures of DNA-bound cytosine and adenine deaminases17,18, we reasoned that the highly flexible U-shaped conformation…

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  • Comparing thermographic heat signatures with joint inflammation detected by ultrasound at the knees in patients with rheumatoid arthritis

    Comparing thermographic heat signatures with joint inflammation detected by ultrasound at the knees in patients with rheumatoid arthritis

    A total of 570 knee (3 aspects per knee) thermograms were obtained while 190 knees (bilaterally) were scanned by ultrasound among 95 RA patients. The patient baseline characteristics and demographic data were as follows: mean (SD) age was 56.7…

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  • Engineering virus-like particles for safe and versatile modeling of SARS-CoV-2 host interaction and immune escape

    Engineering virus-like particles for safe and versatile modeling of SARS-CoV-2 host interaction and immune escape

    Engineering a transcription- and replication-competent virus-like particle (trVLP) system

    We aimed to construct a safe, virus-based platform capable of rapid and straightforward packaging using recombinant DNA. Such a platform should also harness…

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  • Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA

    Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA

    Materials

    1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine (DSPC), 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (DMG-PEG2000), and cholesterol were purchased from AVT (Shanghai) Pharmaceutical Tech Co., Ltd. siPD-L1 and siNC were…

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  • SpaceX launches record-breaking 30th flight of a Falcon 9 booster – Spaceflight Now

    SpaceX launches record-breaking 30th flight of a Falcon 9 booster – Spaceflight Now

    A SpaceX Falcon 9 rocket flies from Launch Complex 39A at NASA’s Kennedy Space Center on the Starlink 10-11 mission. This launch featured the Falcon 9 booster, tail number B1067, making its 30th trip to space and back. Image: John…

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  • Next Week, A Record-Breaking Over 7 Billion People Will See The Total Lunar Eclipse

    Next Week, A Record-Breaking Over 7 Billion People Will See The Total Lunar Eclipse

    Get ready for the Blood Moon next week! Our natural satellite will turn crimson as it is experiencing a total eclipse. It will happen during the evening between September 7 and 8 (depending on the timezone) and will be seen by an enormous number…

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