Engineered dendritic cells called iCAR-DCs integrate tumor-antigen uptake with programmable cell activation in mouse cancer models.
Author: admin
-
Coordinate tumor-antigen uptake and dendritic cell activation by chimeric antigen receptors | Science Translational Medicine
-
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective | Science Translational Medicine
PIEZO1 restoration protects against tyrosine kinase inhibitor–induced endothelial dysfunction, hypertension, and cardiac injury.
Continue Reading
-
How reliable is robotic manipulation in the real world? | Science Robotics
The reliability of manipulation in unstructured environments in unknown, but 1 in 10,000 dropped items may be acceptable.
Continue Reading
-
An orally bioavailable MrgprX1-positive allosteric modulator alleviates certain neuropathic pain–related behaviors in humanized mice | Science Translational Medicine
An orally active positive allosteric modulator of the human Mas-related G protein–coupled receptor X1 is a potential therapy for neuropathic pain.
Continue Reading
-
Single–amino acid variants in target epitopes can confer resistance to antibody-based therapies | Science Translational Medicine
Naturally occurring genetic variants in genes encoding human target antigens can confer resistance to antibody-based therapies.
Continue Reading
-
Distinct systemic immune responses in asymptomatic and symptomatic dengue virus infection | Science Translational Medicine
Systemic immune profiling of individuals with asymptomatic or symptomatic dengue reveals distinct transcriptional patterns.
Continue Reading
-
Learning robot behavior from human-human interactions | Science Robotics
A model trained by observing human-human interactions produces more natural robot behavior during human-robot interaction.
Continue Reading
-
This giant microbe organizes its DNA in a surprising way
3-D microscopy shows that the giant bacterium Thiovulum imperiosus squeezes its DNA into peripheral pouches, not a central mass like typical bacteria.
Continue Reading
-
Where the wild things thrive: Finding and protecting nature’s climate change safe havens
Much wildlife relies on cool streams and lush meadows in the Sierra Nevada. Ron and Patty Thomas/E+ via Getty Images The idea began in California’s Sierra Nevada, a towering spine of rock and ice where rising temperatures and the decline of…
Continue Reading
-
Unpaid caregiving work can feel small and personal, but that doesn’t take away its ethical value
As child care costs outpace wages, more families are facing difficult decisions about whether to scale back work in order to care for loved ones. Caregiving remains the top reason women ages 25-54 leave the workforce.
And it’s not just…
Continue Reading