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  • NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo

    NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo

    NOX1 selectively enriches for LGR5-expressing stem cells in the colon

    To identify markers specifically enriched in colonic stem cells, we profiled the transcriptome of fluorescence-activated cell sorting (FACS)-isolated GFPhigh and GFPneg cell…

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  • The manuring principles in ancient China from the perspective of the San Cai theory

    The manuring principles in ancient China from the perspective of the San Cai theory

    Crops are intricately interconnected with shifts in the natural environment. Throughout the historical development of agriculture, Chinese farmers consistently emphasized that agricultural production should 不违农时(not violate the farming…

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  • Integrating single-cell RNA sequencing and artificial intelligence for multitargeted drug design for combating resistance in liver cancer

    Integrating single-cell RNA sequencing and artificial intelligence for multitargeted drug design for combating resistance in liver cancer

    Data acquisition and preprocessing

    The scRNA-seq dataset GSE166635 is downloaded, containing 25,189 cells from the HCC tumor-adjacent normal tissue (HCC1) and cells from the tumor tissue (HCC2). Cells with fewer than 200 or more than 2500 genes…

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  • Comparative evaluation of impact-based and hybrid approaches for real time earthquake shaking prediction

    Comparative evaluation of impact-based and hybrid approaches for real time earthquake shaking prediction

    The performance of PLUM and QuakeUp was evaluated by examining how each method predicted the ground shaking at key sites in Tottori Prefecture during the 2016 Mjma 6.6 Central Tottori earthquake. Because PLUM does not provide source parameter…

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  • world’s oldest bacterial DNA found in the mouths of mammoths

    world’s oldest bacterial DNA found in the mouths of mammoths

    The DNA of pathogenic bacterial species known to cause blood poisoning in African elephants has been found in the teeth and bones of prehistoric mammoths.Credit: aleks1949/Shutterstock

    An analysis of the bones and teeth of ancient mammoths…

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  • “Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis

    “Good” fats, bad news: HDL-delivered vitamin E shields tumors from ferroptosis

    In a recent study published in Nature, Calhoon et al.1 reported that glycosaminoglycan (GAG)-mediated uptake of lipoproteins protects cancer cells from ferroptosis by delivering α-tocopherol, the…

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  • Neuromorphic pathways for transforming AI hardware

    Neuromorphic pathways for transforming AI hardware

    Neuromorphic pathways for transforming AI hardware

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