MPXV mRNA vaccine design and fusion protein expression
In this study, we developed potent MPXV trivalent mRNA vaccines that target the antigens of both the IMV and EEV forms and characterized their physicochemical properties. First, we generated…
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An unexpected tumor-resistant phenotype from floxing PAK1 in a mouse model of colitis associated cancer
PAK1 is overexpressed in human IBD and CRC5,11,12and we have previously shown that total Pak1 deletion in a mouse model of IBD reduces tumor multiplicity upon AOM/DSS treatment7. However, in IL10KO mice, another mouse model of IBD, Pak1 deletion…
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Non-variational quantum random access optimization with alternating operator ansatz
In this work, we focus on the MaxCut problem, which is commonly used to evaluate both QAOA and QRAO8,9,24,30. However, QAOA-for-QRAO is easily extendable to a broad range of CO problem. Before introducing QAOA-for-QRAO, we briefly explain MaxCut,…
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2D ferroelectric narrow-bandgap semiconductor Wurtzite’ type α-In2Se3 and its silicon-compatible growth
Silicon-compatible large-area synthesis of WZ’ type α-In2Se3 film
In conventional CVD where RTG dominates the growing process (Fig. 1a), the inhomogeneous vapor transport often results in the growing of mixed phases such as β, β’, and α…
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Application of causal forest double machine learning (DML) approach to assess tuberculosis preventive therapy’s impact on ART adherence
Data source and study population
This research employed the University of Gondar Comprehensive and Specialized Hospital, Ethiopia’s electronic medical record system (EMR-ART). Routine secondary data on PLHIV-initiated ART at the hospital between…
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Lipidomic signatures in Octopus vulgaris arm muscle reveal geographic variation along the Iberian Atlantic Coast
Pita, C. et al. Fisheries for common octopus in Europe: socioeconomic importance and management. Fish. Res. 235, 105820 (2021).
WoRMS Editorial Board. World Register of Marine Species.
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Molecular logic gates based on programmable self-assembly of DNA origami triangles for the detection of nucleic acid molecules
Detection of one type of nucleic acid molecules using a YES gate
The programmable detection of nucleic acids using edge-modified triangular DNA origami was demonstrated through structural assembly and logic-gated signal generation. As outlined in…
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Enhancing AI-driven forecasting of diabetes burden: a comparative analysis of deep learning and statistical models
Accurate forecasting of the future burden of diabetes requires addressing the complex temporal dependencies in time-series data. These dependencies emerge from interactions among factors such as prevalence, mortality rates, and…
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Applications of bamboo fiber and bamboo stem ash with styrene butadiene rubber in cement mortar for sustainable structural application
Computation of dry density with experimental results and Taguchi analysis
Figure 10 presents the experimental results for all control and trial mixes with different proportions of BF and BSA. The bulk density of BSA (651 kg/m³) is notably lower…
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Exploring the feasibility of AI-based analysis of histopathological variability in salivary gland tumours
Computational pathology (ML, DL, and AI) has been shown to provide objective and accurate quantification and classification in a range of cancers5,6,7,8,9,25,26,27,28,29,30,−31. This study presents a novel application of AI, integrating ML and…
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