The chikungunya (CHIKV) outbreak in China, with more than 7,000 cases reported in Guangdong province since July, is a stark reminder of how ecological shifts and global connectivity amplify infectious-disease risks. The rapid spread reflects the…
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A dataset of spatially resolved transcriptomics of post-natal cardiac development in mice
Animals
In this study, wild-type C57BL/6J mice at three post-natal developmental stages, including post-natal day 0 (P0), post-natal day 7 (P7), and post-natal day 56 (P56) were used. The mice were supplied by Chengdu Gempharmatech Co. and housed…
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Circular RNA RORβ regulates TGFβR1 in alcohol-induced fibroblast-to-myofibroblast differentiation
Chronic alcohol ingestion increases the risk of developing Acute Respiratory Distress Syndrome (ARDS) in clinical setting3. In an experimental model, we showed that alcohol ‘ethanol’ promoted fibroproliferative disrepair through induction of…
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A Nostalgia Brain-Music Interface for enhancing nostalgia, well-being, and memory vividness in younger and older individuals
Nostalgia Brain-Music Interface (N-BMI)
Overview
The proposed Nostalgia Brain-Music Interface (N-BMI) consisted of three steps, referred to as ‘Rec-Dec-Back’: (1) recording, (2) decoding, and (3) feedback (Fig. 1). Before the experiment,…
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Mechanical response mechanism and parameter optimization of double-arch tunnels without middle drift during construction
Stability analysis of excavation
Settlement evolution of the surrounding rock
Figure 9 shows the displacement evolution of the surrounding rock at arch crown of the left and right tunnels during the simulated excavation process of the double-arch…
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Optimization model for predicting quantum theoretic characteristics of hexagonal systems using temperature dependent graph theoretic estimators
Note that, within a range of \(\theta\) values, both the temperature indices \(T^{\theta }_{1}\) and \(T^{\theta }_{2}\) deliver a significant predictive accuracy for correlating \(E_{\pi }\) of lower BHs.
Let us first evaluate the exact…
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Beta blockers linked to reduced 1-Year mortality in critically ill congestive heart failure patients with differential benefits across subgroups
In this extensive cohort, the use of β blockers was associated with reduced 1-year all-cause mortality in critically ill patients with CHF. This benefit was particularly pronounced in subgroups characterized by younger age, male gender,…
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Generalized modeling of carbon film deposition growth via hybrid MD/MC simulations with machine-learning potentials
Workflow fitted for the NEP model
As illustrated in Fig. 1, an active learning workflow was employed to develop a high-accuracy MLP for carbon deposition. This framework iteratively integrates NEP training and DFT validation during hybrid MD/tfMC…
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Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma
This research complies with all relevant ethical regulations. The MUPPITS-2 study protocol was approved by the Western Institutional Review Board2.
Study design
The MUPPITS-2 (Mechanisms Underlying Asthma Exacerbations Prevented and Persistent with…
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AI-powered brain device allows paralysed man to control robotic arm
The performance of non-invasive brain devices can be improved by combining them with AI.Credit: Jean-Pierre Clatot/AFP via Getty
A man with partial paralysis was able operate a robotic arm when he used a non-invasive brain device partially…
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