The Matteson homologation, first developed in 1980, elongates carbon chains by insertion into a C−B bond.1 This versatile reaction traditionally requires three steps: carbanion formation, nucleophilic addition to organoboron, and a thermo- or…
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Insights into DNA repeat expansions among 900,000 biobank participants
Depienne, C. & Mandel, J.-L. 30 years of repeat expansion disorders: what have we learned and what are the remaining challenges? Am. J. Hum. Genet. 108, 764–785 (2021).
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Systematic analyses of lipid mobilization by human lipid transfer proteins
Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and auxiliary lipids facilitating transfer remain unknown. We…
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Neuro-epithelial circuits promote sensory convergence and intestinal immunity
Gieseck, R. L. 3rd, Wilson, M. S. & Wynn, T. A. Type 2 immunity in tissue repair and fibrosis. Nat. Rev. Immunol. 18, 62–76 (2018).
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Hammad, H., Debeuf, N.,…
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Early hominins from Morocco basal to the Homo sapiens lineage
Meyer, M. et al. Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins. Nature 531, 504–507 (2016).
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Duval, M. et al. The…
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Aharonov–Bohm interference in even-denominator fractional quantum Hall states
Feldman, D. E. & Halperin, B. I. Fractional charge and fractional statistics in the quantum Hall effects. Rep. Prog. Phys. 84, 076501 (2021).
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Nayak, C.,…
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RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity
Orthologue identification, phylogenetic analysis and sequence alignment
We used previously identified Cas12a2 protein sequences27 as queries for tBLASTn and BLASTp searches in the NCBI databases (https://www.ncbi.nlm.nih.gov) and the JGI…
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Plastic landmark anchoring in zebrafish compass neurons
Animal husbandry
The animal handling and experiments were performed according to protocols approved by the animal welfare officer at Institüt für Neurowissenschaften, Technische Universität München (TUM) and the relevant department at the…
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A young progenitor for the most common planetary systems in the Galaxy
Transit observations and analysis
We analysed a heterogeneous dataset of light curves from space- and ground-based telescopes (Supplementary Table 1) to measure transit times for the ultimate purpose of modelling TTVs. We used PyMC344, exoplanet (
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A framework for addressing racial and related inequities in conservation
Western, D., Wright, R. M. & Strum, S. C. (eds). Natural Connections: Perspectives in Community-Based Conservation (Island Press, 1994).
Jonas, H., Makagon, J. & Roe, D. in Conservation standards: From Rights to Responsibilities (International…
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