HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.
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HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment | Science Translational Medicine
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Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice | Science Translational Medicine
CNS-targeted hematopoietic stem cell gene therapy shows efficacy in a mouse model of progranulin-related neurodegenerative disease.
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Extracellular BRICK1 drives heart repair after myocardial infarction in mice | Science Translational Medicine
The WAVE complex subunit BRICK1 functions as an angiogenic factor driving heart repair after myocardial infarction.
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Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects | Science Translational Medicine
Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and viral fitness impacts.
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PET/CT imaging of tuberculosis lung lesions in marmosets treated with different drug regimens aligns with human clinical outcomes | Science Translational Medicine
Longitudinal PET/CT imaging data from the lungs of infected marmosets align with clinical treatment outcomes in patients with TB.
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Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions | Science Translational Medicine
Four months instead of the standard 6 months of drug therapy of less extensive tuberculosis disease had a higher risk of relapse.
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When HIV pays the price: Fitness costs behind lenacapavir resistance | Science Translational Medicine
HIV can take several mutational pathways to become resistant to lenacapavir, each with distinct resistance and fitness profiles (Pennetzdorfer et al., this issue).
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Erratum for Research Article "Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair" by K. Mylonas et al. | Science Translational Medicine
In the Research Article “Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair” by K. Mylonas et al., an inadvertent image duplication affected Fig. 3C. An immunofluorescent image of…
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Deploying a hybrid approach to Web3 in the AI era
What was once a futuristic concept is quickly becoming a more concrete reality, even at a time when Web2 still dominates. Six out of ten Fortune 500 companies are exploring blockchain-based solutions, most taking a hybrid approach that…
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Hearing Aids Will Use Biosignals to Ease Mental Strain
Imagine you’re at a bustling dinner party filled with laughter, music, and clinking silverware. You’re trying to follow a conversation across the table, but every word feels like it’s wrapped in noise. For most people, these types of party…
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