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  • Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance

    Structural basis of VCP-VCPIP1-p47 ternary complex in Golgi maintenance

    Cloning, protein expression and purification

    Full-length VCPIP1 in pDEST_CMV with a N-terminal Strep tag was acquired from Wade Harper67 and VCP was a gift from Nico Dantuma (VCP in pEGFP-N1 [Addgene plasmid #23971]). From there, the VCP coding…

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  • AI-Driven Tai Chi mastery using deep learning framework for movement assessment and personalized training

    AI-Driven Tai Chi mastery using deep learning framework for movement assessment and personalized training

    Tai Chi movement assessment neural network model design

    Our neural network model for Tai Chi movement assessment builds upon the Spatial-Temporal Graph Convolutional Network (ST-GCN) architecture, enhanced with attention mechanisms to capture the…

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  • Bridging known and unknown dynamics by transformer-based machine-learning inference from sparse observations

    Bridging known and unknown dynamics by transformer-based machine-learning inference from sparse observations

    Hybrid machine learning

    Consider a nonlinear dynamical system described by

    $$\frac{d{{{\bf{x}}}}(t)}{dt}={{{\bf{F}}}}({{{\bf{x}}}}(t),t),\quad t\in [0,T],$$

    (3)

    where \({{{\bf{x}}}}(t)\in {{\mathbb{R}}}^{D}\) is…

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  • Linking cardiological parameters and choroidal changes in patients with precapillary pulmonary hypertension: a cross-sectional study

    Linking cardiological parameters and choroidal changes in patients with precapillary pulmonary hypertension: a cross-sectional study

    This prospective, single-center, cross-sectional study was conducted between 2021 and 2023 at the Ophthalmology Department of the Medical University of Bialystok. The study involved 29 adult PPH patients admitted for routine clinical assessment…

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  • Cross-talk between dopamine and noradrenaline modulates glutamatergic transmission in the deep cerebellar nuclei

    Cross-talk between dopamine and noradrenaline modulates glutamatergic transmission in the deep cerebellar nuclei

  • Nieoullon, A., Cheramy, A. & Glowinski, J. Release of dopamine in both caudate nuclei and both substantia nigrae in response to unilateral stimulation of cerebellar nuclei in the cat. Brain Res. 148, 143–152 (1978).

    CAS 
    PubMed 

    …

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  • Climate risk adaptation in dryland maize through cultivar adoption

    Climate risk adaptation in dryland maize through cultivar adoption

    Data on the national total area of maize planted (AN, ha) and commercial production (PN, t) in the 100 crop seasons from 1922–23 to 2021–22 were obtained from the Crop Estimates Committee of South Africa (

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  • This deep-sea worm creates a toxic yellow pigment found in Rembrandt and Cézanne paintings

    This deep-sea worm creates a toxic yellow pigment found in Rembrandt and Cézanne paintings

    Paralvinella hessleri accumulates microscopic particles of arsenic on its outer skin, which reacts with sulfide to form a microscopic armour of yellow orpiment.Credit: Wang et al./PLoS Biol (CC BY 4.0)

    A bright-yellow worm that lives in deep-sea…

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  • Deepath-MSI: a clinic-ready deep learning model for microsatellite instability detection in colorectal cancer using whole-slide imaging

    Deepath-MSI: a clinic-ready deep learning model for microsatellite instability detection in colorectal cancer using whole-slide imaging

    Cohort description

    In this multicenter retrospective study, we collected H&E-stained slides from formalin-fixed paraffin-embedded tissue sample obtained from seven independent CRC patient cohorts. Six of seven cohorts were derived from five…

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