Single-immunocyte transcriptional profiling
First, we conducted a scRNA-seq to investigate the transcriptomic characteristics of PBMCs from 14 patients and 3 HDs (Fig. 1a and Supplementary Table 1). Patients with AS were divided into three groups…

First, we conducted a scRNA-seq to investigate the transcriptomic characteristics of PBMCs from 14 patients and 3 HDs (Fig. 1a and Supplementary Table 1). Patients with AS were divided into three groups…

In recent years, several studies have revealed that loss of β-cell identity is a major determinant of β-cell failure.6,10,15,39 To characterize the dynamic process of β-cell…

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