A global effort to create a “microbial Noah’s Ark” to preserve the world’s diverse collection of healthy microbes before they disappear is now entering an active growth phase.
In a perspective article published in Nature…
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Advancing transdermal insulin delivery through innovative formulation strategies
Announcing a new publication for Acta Materia Medica journal. The prevalence of diabetes is increasing and expected to become a major global health burden. Various pharmaceutical approaches have been used to manage diabetes and…
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FAM111B identified as a key driver of glioma progression and therapeutic target
Gliomas are among the deadliest brain tumors, with limited treatment options and poor survival rates. Scientists from China identified FAM111B, a DNA-repair-associated protein, as a key driver of glioma progression. The study shows…
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Proteome imbalance from aneuploidy linked to mitochondrial dysfunction
It has been known for several years that abnormal chromosome numbers lead to protein imbalances in the affected cells. Researchers at RPTU have now investigated the detailed effects of such imbalances. Surprisingly, they found that…
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New enzyme can be “turned off” to restore cholesterol balance and reduce inflammation
Scientists at The University of Texas at Arlington have identified a new enzyme that can be “turned off” to help the body maintain healthy cholesterol levels-a significant development that could lead to new treatments for diseases…
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Early HHV-6 reactivation increases the risk of graft rejection after haploidentical hematopoietic cell transplantation
Ward KN, Hill JA, Hubacek P, de la Camara R, Crocchiolo R, Einsele H, et al. Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after…
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Epigenetic regulators in cancer therapy and progression
Bates, S. E. Epigenetic therapies for cancer. N. Engl. J. Med. 383, 650–663 (2020).
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Waddington, C. H. The epigenotype. Int. J. Epidemiol. 41, 10–13 (2012).
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User acceptance of battery swapping in battery electric vehicles among private users in Germany
As mentioned earlier, swappable batteries are not yet widespread in Germany and are unknown to large parts of the population. The following section, therefore, places particular focus on factors influencing the acceptance of e-mobility in general…
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Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis
Chromosome Y loss in blood leukocytes is associated with the risk for IPF
We first investigated IPF in relation to mLOY in the prospective UKB cohort with participants from the general population. Among 407,034 participants included in the present…
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Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues
The role of the CDK4/6-RB pathway and cell cycle proteins in cancer
Most adult tissues consist of G0 phase cells, either in a permanent state from terminal differentiation or senescence, or in a temporary, reversible state known as quiescence….
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