Brown fat-specific loss of SENP2 does not affect adipogenesis but affects expression of genes involved in thermogenesis and oxidative phosphorylation
To elucidate the role of SENP2 in BAT metabolism, we generated a brown adipocyte-specific Senp2…
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How and when organisms edit their own genomes
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An, R. et al. Non-enzymatic depurination of nucleic acids:…
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Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism
Identification of circIGF1R in heart failure tissue and validation of its circular conformation
Global RNA sequencing was performed using left ventricular cardiac tissue from HF patients (in comparison to that of healthy controls) to evaluate the…
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The singing style of female roles in ethnic opera under artificial intelligence and deep neural networks
Datasets collection
This work conducts experiments using two datasets: the publicly available MagnaTagATune dataset and a self-built dataset, the Self-built Ethnic Opera Female Role Singing Excerpt Dataset (SEOFRS). The MagnaTagATune dataset is a…
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Lessons from incretin-based therapy in MASH and obesity
Ussher, J. R. & Drucker, D. J. Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action. Nat. Rev. Cardiol. 20, 463–474 (2023).
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Improving engineered biological systems with electronics and microfluidics
Cameron, D. E., Bashor, C. J. & Collins, J. J. A brief history of synthetic biology. Nat. Rev. Microbiol. 12, 381–390 (2014).
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Brophy, J. A. N. & Voigt, C….
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Beyond planar: fish schools adopt ladder formations in 3D
Fish care
In our experiments, we used giant danio (Devario aequipinnatus) that were 6.0 ± 0.6 cm long, 0.7 ± 0.1 cm wide, and 1.3 ± 0.1 cm tall. They were acquired from a local commercial supplier near Boston, Massachusetts, United States of…
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Advancing cancer research via comparative oncology
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Smith, E. F. Further evidence that crown gall of plants is cancer….
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AAV mini-dystrophin gene therapy for Duchenne muscular dystrophy: a phase 1b trial
Study design and oversight
This ongoing, nonrandomized, open-label, ascending-dose, phase 1b study (ClinicalTrials.gov registration no. NCT03362502) was initiated in January 2018 at three sites in the United States (Supplementary Fig. 3 and…
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Chikungunya virus burden and implications for vaccination programs
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Ribeiro dos Santos, G. et al. Global burden of chikungunya virus infections and the…
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