Thank you to all LGBTQIA+ health researchers and those affected by grant terminations for their continued leadership in their respective fields. A special thank you to the LGBTQIA+ communities who continue to embrace us even as we are losing…
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p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2+ breast cancer that limits trastuzumab deruxtecan efficacy
Goutsouliak, K. et al. Towards personalized treatment for early stage HER2-positive breast cancer. Nat. Rev. Clin. Oncol. 17, 233–250 (2020).
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Rimawi, M. F., Schiff,…
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ADAT3-related neurodevelopmental disorder in 24 new patients with a high frequency of the p.Val144Met and a new founder variant
ADAT3-related neurodevelopmental disorder is very rare with only 60 patients from 29 unrelated families reported in the literature4,5,7,8,10,11,12,13,27. Our study reports an additional 24 patients and significantly substantiates the clinical and…
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An experimental proxy of water displaceability for ligand discovery
Lee, Y.-H. et al. Crystal structure of a trapped phosphoenzyme during a catalytic reaction. Nat. Struct. Biol. 4, 615–618 (1997).
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Keedy, D. A. et al….
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The synaptonemal complex central element SCEP3 interlinks synapsis initiation and crossover formation in Arabidopsis thaliana
Zickler, D. & Kleckner, N. Meiosis: dances between homologs. Annu. Rev. Genet. 57, 1–63 (2023).
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de Massy, B. Initiation of meiotic recombination: how and…
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Movement-responsive deep brain stimulation for Parkinson’s disease using a remotely optimized neural decoder
Ashkan, K., Rogers, P., Bergman, H. & Ughratdar, I. Insights into the mechanisms of deep brain stimulation. Nat. Rev. Neurol. 13, 548–554 (2017).
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McGregor, M. M. &…
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Harnessing computational technologies to facilitate antibody–drug conjugate development
Corrie, P. G. Cytotoxic chemotherapy: clinical aspects. Medicine 39, 717–722 (2011).
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Saeed, R. F. et al. Targeted therapy and personalized medicine. Cancer Treat. Res. 185,…
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Reshaping the tumor microenvironment of cold soft-tissue sarcomas with anti-angiogenics: a phase 2 trial of regorafenib combined with avelumab
Study design and participants
The REGOMUNE trial is a multi-cohort study comprising 17 parallel, single-arm phase 2 trials, with the purpose of evaluating the safety and efficacy of combining regorafenib with avelumab across various tumor types….
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Synthesis, cytotoxic screening and molecular docking, DFT calculation of novel furan-heterocyclic derivatives as insecticidal agents
General remarks
Melting points were determined on a Gallenkamp electric apparatus. IR spectra (KBr discs) were measured Thermo Scientific Nicolet iS10 FTIR spectrometer. Also, Bruker’s spectrometer 400 MHz, and JEOL spectrometer 500 MHz and…
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The promise and challenges of psychedelic-assisted therapy: lessons from Canada’s Special Access Program
The promise and challenges of psychedelic-assisted therapy: lessons from Canada’s Special Access Program
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