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  • Pharmacophore-oriented 3D molecular generation toward efficient feature-customized drug discovery

    Pharmacophore-oriented 3D molecular generation toward efficient feature-customized drug discovery

  • Berdigaliyev, N. & Aljofan, M. An overview of drug discovery and development. Future Med. Chem. 12, 939–947 (2020).

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  • Goodnow, J. R. A. Hit and lead identification: integrated technology-based…

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  • Efficacy and safety of a novel flow-disruptor device in a rabbit aneurysm model: a preliminary study

    Efficacy and safety of a novel flow-disruptor device in a rabbit aneurysm model: a preliminary study

    Preparation of the NFD

    The NFD was designed by combining the intrasaccular shape of the WEB device with the conical configuration of the Contour, which crosses the aneurysmal neck. The NFD embolization device was constructed using a double-layer…

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  • Processing in working memory boosts long-term memory representations and their retrieval

    Processing in working memory boosts long-term memory representations and their retrieval

    Participants—Experiments 1 and 2

    In Experiment 1, data were collected from 49 participants, with six excluded: four due to EEG recording failures resulting in data loss, and two due to misunderstanding the task. One person consistently pressed…

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  • Disease-specific genetic diagnostic strategies for muscle diseases unresolved by short-read sequencing

    Disease-specific genetic diagnostic strategies for muscle diseases unresolved by short-read sequencing

  • Nishikawa A, Mitsuhashi S, Miyata N, Nishino I. Targeted massively parallel sequencing and histological assessment of skeletal muscles for the molecular diagnosis of inherited muscle disorders. J Med Genet. 2017;54:104–10.

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  • Oxic microbial ferrihydrite reduction rates of Shewanella oneidensis and the potential for Fe mobilization in oxic sediments

    Oxic microbial ferrihydrite reduction rates of Shewanella oneidensis and the potential for Fe mobilization in oxic sediments

    Experimental medium

    A liquid medium was prepared with deionized water, 10% v/v Luria Bertani broth (LB, Sigma Aldrich), and 20 mM PIPES (piperazine-N, N′-bis(2-ethanesulfonic) acid, Thermo Scientific). After adjusting the pH to ~ 7.1 using HCl…

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  • SpyShield: a Spyfall inspired defense mechanism against poisoning attacks in federated learning

    SpyShield: a Spyfall inspired defense mechanism against poisoning attacks in federated learning

    In the reviewed literature on defending against poisoning attacks in FL, all approaches, including those in9,43,44, are implemented solely on the server without any assistance from clients. However, it is reasonable to collaborate with clients…

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  • Virtual reality-based cue exposure therapy reduces psychological craving in men with methamphetamine use disorder: a randomized controlled trial

    Virtual reality-based cue exposure therapy reduces psychological craving in men with methamphetamine use disorder: a randomized controlled trial

    Study design and registration

    This randomized controlled trial was registered with the Chinese Clinical Trial Registry (ChiCTR1800020014) and approved by the Ethics Committee of the Second Xiangya Hospital of Central South University (approval…

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  • Boosting the influenza vaccine schedule in children with cancer: a prospective open-label study

    Boosting the influenza vaccine schedule in children with cancer: a prospective open-label study

  • Furlong, E. & Kotecha, R. S. Lessons learnt from influenza vaccination in immunocompromised children undergoing treatment for cancer. Lancet Child Adolesc. Health 7, 199–213 (2023).

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  • Scalable total synthesis of saxitoxin and related natural products

    Scalable total synthesis of saxitoxin and related natural products

    Saxitoxin (STX, 1), a potent neurotoxin from shellfish, first isolated in 19571, offers immense pharmaceutical potential due to its interaction with voltage-gated sodium channels2, that are ubiquitously present in all excitable cells of the…

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