A HTS cell-based assay to identify HIV-1 Gag-Pol dimerizers promoting HIV-1 protease activation of CARD8 inflammasome pathway and pyroptosis
We generated a unique cell-based system to search for more potent chemicals that activate the CARD8…
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A graph neural network recommendation algorithm based on multi-scale attention and contrastive learning
In this section, we specifically describe the proposed Graph Neural Network-based recommendation algorithm (GR-MC), which incorporates multi-scale attention and contrastive learning, and explain how it addresses several key issues in existing…
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Valorization of novel bifunctional waterborne coatings with UV irradiation resistance and antimicrobial activity
Color investigation
The protective effect of the prepared coatings is investigated by determining the color change after the exposure to UV irradiation during 500 h. As shown in Fig. 2, all the coatings have positive a* values, which confirms the…
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Colonial-era settlements and post-colonial legacies have increased the loss of montane forests in the central highlands of Kenya
Malhi, Y., Gardner, T. A., Goldsmith, G. R., Silman, M. R. & Zelazowski, P. Tropical forests in the anthropocene. Annu. Rev. Environ. Resour. 39, 125–159 (2014).
Roberts, P. et al. Mapping…
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Support-tuned iridium reconstruction with crystalline phase dominating acidic oxygen evolution
Chemicals and materials
Ethylene glycol (C2H6O2, AR) was purchased from Beijing Chemical Factory. Absolute ethanol (C2H6O, AR) and isopropyl alcohol (C3H8O, AR) were purchased from Sinopharm Chemical Reagent Co., Ltd. Ti nanospheres (Ti, ≥99.8%…
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Pythia provides deep learning-driven precision in CRISPR–Cas9 genome engineering
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Naert, T. et al. Precise, predictable genome integrations by deep-learning-assisted…
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Identification of candidate gene networks affecting the number of somatic cells count and milk production in Iranian Holstein cows using Genome-wide association study
Buaban, S., Lengnudum, K., Boonkum, W. & Phakdeedindan, P. Genome-wide association study on milk production and somatic cell score for Thai dairy cattle using weighted single-step approach with random regression test-day model. J. Dairy Sci.…
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Inverted temperature gradients in gold–palladium antenna-reactor nanoparticles
Zhan, C. et al. Plasmon-mediated chemical reactions. Nat. Rev. Methods Prim. 3, 1–21 (2023).
Christopher, P., Xin, H., Marimuthu, A. & Linic, S. Singular characteristics and unique chemical…
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SlimVar for rapid in vivo single-molecule tracking of chromatin regulators in plants
SlimVar enables molecular quantification of diffusing particles deep in tissue
SlimVar is a 2D+ time imaging technique which identifies fluorescent foci from local intensity maxima in each video frame (Fig. 1, Table 1). Foci correspond to at…
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Structured AI decision-making in disaster management
This section details the methodology followed in the implementation and evaluation of the proposed framework. The framework involves Enabler agents and Decision Maker agents collaborating across multiple Levels in a tree-like Scenario structure….
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