Trial design and population
This study employed a phase design and included three independent cohorts (Fig. 1). The study was approved by the centralized institutional review board (IRB) covering 20 participating centers (IRB-2024-279,…
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Racial differences in serological markers across the first year of injury in spinal cord injury: responses to the letter to editor
Krause JS, Dismuke-Greer CE, Jarnecke M, Reed KS. Differential odds of employment and estimation of earnings among those with spinal cord injury. Rehabil Couns Bull. 2020;63:67–78. https://doi.org/10.1177/0034355219848493
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Unpicking the effects of FGF21 on longevity
Fibroblast growth factor 21 (FGF21) is a hormone that is known to have positive effects on metabolism and lifespan. However, so far it has not been possible to isolate the effects of FGF21 on longevity from its developmental functions. A new…
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Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles
Andre, F. et al. Genomics to select treatment for patients with metastatic breast cancer. Nature 610, 343–348 (2022).
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Ganesh, K. & Massagué, J. Targeting…
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AI, neurotechnology and society — a question of trust
Lucas, A., Revell, A. & Davis, K. A. Artificial intelligence in epilepsy — applications and pathways to the clinic. Nat. Rev. Neurol. 20, 319–336 (2024).
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Cysteine deficiency induces rapid weight loss via adipose tissue browning
A new study in Nature Metabolism identifies a mechanism by which depletion of cysteine (a thiol-containing amino acid), which is believed to be essential for systemic metabolism, leads to rapid weight loss and adipose tissue browning.
The…
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Preclinical evaluation of lentiviral gene therapy for adenosine deaminase 2 deficiency (DADA2): engraftment efficiency and biodistribution in humanised NBSGW mice
Patient samples
This study was approved by the Bloomsbury Ethics Committee (no. 08H071382). CD34 + HSC were obtained from the bone marrow of a 3-month-old severe DADA2 patient presenting with Pure Red-Cell Aplasia (PRCA) (genotype ADA2…
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Training physician-scientists, a view from inside
Physician-scientists are essential for translating research into clinical practice, yet recent US policy changes, combined with a protracted training path, threaten the stability of the current workforce and the ability to train their successors….
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Neuroimaging insights into brain mechanisms of early-onset restrictive eating disorders
Sample characteristics
Our analysis included 290 participants (124 EO-AN, 50 ARFID and 116 TD) (Table 1). As expected, EO-AN and ARFID had a significantly lower mean z-scored BMI compared with TD (BMI of −1.81 (95% confidence interval (CI)…
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The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types
Boutros, A. et al. The treatment of advanced melanoma: current approaches and new challenges. Crit. Rev. Oncol. Hematol. 196, 104276 (2024).
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Powles, T. et al. ESMO…
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