Tissue levels of deoxynucleotide triphosphates (dNTPs) are tightly regulated, and their dysregulation can impair DNA replication, leading to DNA damage and genetic instability. dNTPs can be synthesized de novo in a cell-autonomous pathway,…
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How to spy on condensates
Condensates can appear homogeneous in texture, but that misses the whole picture, as Ke Xu of the University of California, Berkeley and his team have found6. They experimented with droplets in vitro and developed a way to get FUS, an RNA-binding…
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Calopy — an advanced framework for the integration and analysis of indirect calorimetry data
Calopy — an advanced framework for the integration and analysis of indirect calorimetry data
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A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1
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Ancient DNA reveals diverse community organizations in the 5th millennium BCE Carpathian Basin
Szécsényi-Nagy, A. et al. Tracing the genetic origin of Europe’s first farmers reveals insights into their social organization. Proc. R. Soc. B 282, 20150339 (2015).
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Allogenic mitochondria transfer improves cardiac function in iPS-cell-differentiated cardiomyocytes of a patient with Barth syndrome
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Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
Guerreiro, R. et al. TREM2 variants in Alzheimer’s disease. N. Engl. J. Med. 368, 117–127 (2013).
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Hollingworth, P. et al. Common variants at ABCA7,…
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HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors
Structural homology
DNASTAR Navigator-17 Lasergene software®, supported by the ISU Pharmaceutical Sciences Computational Core Laboratory, was used for structural and sequence homology studies62. DNASTAR’s integral Protean 3D application was…
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Comparison of induction with arsenic trioxide or chemotherapy in a real-world cohort of patients with high-risk acute promyelocytic leukemia
Adès L, Thomas X, Bresler AG, Raffoux E, Spertini O, Vey N, et al. Arsenic trioxide is required in the treatment of newly diagnosed acute promyelocytic leukemia. Analysis of a randomized trial (APL 2006) by the French Belgian Swiss APL group….
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Metabolic Messengers: oestradiol | Nature Metabolism
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