While terms like “uncertainty” and “safety” appear in AI governance policies4,5 and tools exist to identify potential legal risks of AI solutions15, formal risk assessments of AI solutions under consideration are rare. However, we believe…
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Membrane-initiated estrogen receptor-α signaling in osteoblasts is crucial for normal regulation of the cortical bone in female mice
Animals
Generation of a conditional C451A mERα knockout mouse model
To generate a transgenic mouse model facilitating a conditional amino acid shift (cysteine > alanine) at site 451 (C451A) in Esr1 by introducing the mutation TGC > GCA, a…
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Structural polymorphism of the antigenic loop in HBV surface antigen dictates binding of diverse neutralizing antibodies
Cell culture
Sf9 insect cells (Thermo Fisher Scientific) were cultured in SIM SF (Sino Biological) at 27 °C. FreeStyle 293 F suspension cells (Thermo Fisher Scientific) were cultured in FreeStyle 293 medium (Thermo Fisher Scientific)…
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Spin-orbital excitations encoding the magnetic phase transition in the van der Waals antiferromagnet FePS3
Bhimanapati, G. R. et al. Recent advances in two-dimensional materials beyond graphene. ACS Nano 9, 11509–11539 (2015).
Huang, B. et al. Layer-dependent ferromagnetism in a van der Waals…
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Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis
Cell culture and regents
Human lung cancer cell lines including HCC827, NCI-H23, PC9, NCI-H1975, NCI-H3122, NCI-H2087, Calu-1, Calu-3, NCI-H1299, NCI-H358, NCI-H460 and A549 were obtained from ZQXZBIO, Shanghai, China. For lentivirus package,…
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Battery-free and self-propelled bionic microneedle system for chemically controlled on‐demand drug delivery
System overview
This work introduces a streamlined BSBMs, engineered for self-powered and on-demand controlled drug delivery without the need for external activation and pumping equipment. The BSBMs is inspired by the venom injection mechanism of…
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