Selection of the KA-11-MAP8 peptide
Syntenin-1 is a 298 amino acid protein identified as a tumor antigen that promotes tumor proliferation, migration, and metastasis. Initially, we performed ab initio modeling of the 3D structure of Syntenin-1…
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Reply to: Mass spectrometry and enzyme assays refute histone tyrosine sulfation
Yu, W. X. et al. Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription. Nat. Chem. Biol. 19, 855–864 (2023) ; erratum 19, 1286 (2023).
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Lifetime expression of egg rejection behaviour in Eurasian magpies is associated with variation in a polymorphic genetic marker
Rothstein, S. I. Mechanisms of avian egg recognition: Possible learned and innate factors. Auk 91, 796–807 (1974).
Brooke, M. D. L. & Davies, N. B. Egg mimicry by cuckoos Cuculus Canorus in…
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Mechanistic basis for a novel dual-function Gag-Pol dimerizer potentiating CARD8 inflammasome activation and clearance of HIV-infected cells
A HTS cell-based assay to identify HIV-1 Gag-Pol dimerizers promoting HIV-1 protease activation of CARD8 inflammasome pathway and pyroptosis
We generated a unique cell-based system to search for more potent chemicals that activate the CARD8…
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How ageing changes our genes — huge epigenetic atlas gives clearest picture yet
A huge analysis of DNA methylation in human tissue has revealed new anti-ageing targets.Credit: Lawrence Lawry/SPL
The visible effects of ageing on our body are in part linked to invisible changes in gene activity. The epigenetic process of DNA…
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High-fidelity Cas9-mediated targeting of KRAS driver mutations restrains lung cancer in preclinical models
CRISPR-HiFiCas9 enables robust and highly specific targeting of KRAS driver mutations
The KRASG12C and KRASG12D point mutations differ from the KRASWT sequence by only a single nucleotide (Fig. 1A). To ensure the therapeutic approach is selective…
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Ferroaxial density wave from intertwined charge and orbital order in rare-earth tritellurides
Fradkin, E., Kivelson, S. A. & Tranquada, J. M. Colloquium: theory of intertwined orders in high temperature superconductors. Rev. Mod. Phys. 87, 457 (2015).
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Comin, R. et al. Symmetry…
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Peptidoglycan-reshuffling proteins SCO0954, SCO1758, SCO4439, and SCO4440 modulate the formation of wall-deficient cells in Streptomyces coelicolor under hyperosmotic sucrose stress
The sco1760::Tn5, and sco4439/40::Tn5062 knockout mutants, as well as S.
coelicolor overexpressing sco0954, exhibit hyphal bulging and the formation of large distinct round cells under conditions of hyperosmotic…Continue Reading
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Inverted temperature gradients in gold–palladium antenna-reactor nanoparticles
Zhan, C. et al. Plasmon-mediated chemical reactions. Nat. Rev. Methods Prim. 3, 1–21 (2023).
Christopher, P., Xin, H., Marimuthu, A. & Linic, S. Singular characteristics and unique chemical…
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Optimization of protease production by newly isolated Bacillus sp. from the Red Sea using defatted soybean cake
Rao, M. B., Tanksale, A. M., Ghatge, M. S. & Deshpande, V. V. Molecular and biotechnological aspects of microbial proteases. Microbiol. Mol. Biol. Rev. 62, 597–635. https://doi.org/10.1128/mmbr.62.3.597-635.1998 (1998).
Kumar, D., Savitri,…
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