Study design, setting, data sources, and period
In this retrospective cohort study, we used data from the DeSC database from April 2014 to December 2022. The DeSC database is a large commercial medical claims database provided by DeSC Healthcare…
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Psychometric validity of the Perceived Home Management Hassles Scale
In this study, we used data from a convenience sample in a one-time survey to clarify the structural validity, internal consistency, and construct validity of the Perceived Home Management Hassles Scale as a part of its psychometric evaluation….
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Comprehensive analysis of MAGE-A10 in pan-cancer and its validation in gastric cancer
MAGE-A10 expression and localization in normal and pan-cancer tissues
Analysis of HPA and Genotype-Tissue Expression (GTEx) data revealed high expression of MAGE-A10 in normal placental and testicular tissues (Fig. 2A). Immunohistochemical…
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Sustainable biodiesel production from cottonseed oil using a nickel-doped eggshell heterogeneous catalyst optimized via response surface methodology
This study aimed to investigate the relationship between particle size and catalyst weight%, followed by catalyst characterization using scanning electron microscopy (SEM) and X-ray diffraction (XRD). A proximate analysis of cottonseed was…
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Interpretable AI-assisted diagnosis of papillary thyroid cancer cytopathology using graph neural networks and knowledge graphs
The global rise in the detection of thyroid nodules has made fine-needle aspiration cytology (FNAC) the gold standard for preoperative diagnosis due to its safety and accuracy1. However, obtaining high-quality, labeled datasets for deep learning…
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Pythia provides deep learning-driven precision in CRISPR–Cas9 genome engineering
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Naert, T. et al. Precise, predictable genome integrations by deep-learning-assisted…
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Explainable self-supervised learning for medical image diagnosis based on DINO V2 model and semantic search
Experimental setup
All experiments were conducted on 4 × NVIDIA V100 GPUs (32GB VRAM) with the following considerations: (1) DINOv2 training used a batch size of 32 (Sect. “Proposed work”) to balance memory constraints with gradient…
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Functional phenotyping of genomic variants using joint multiomic single-cell DNA–RNA sequencing
SDR-seq protocol
A detailed protocol for SDR-seq is published on protocols.oi at https://doi.org/10.17504/protocols.io.6qpvr9q43vmk/v1.
Cell culture
WTC-11 iPS cells (Coriell Institute for Medical Research, GM25256) were verified to display a normal…
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Lead-free perovskite KCsSnI1.7Cl1.3 material exhibiting superior photocatalytic antimicrobial activity
Characterization
The XRD of the prepared lead-free perovskite KCsSnI1.7Cl1.3 nanomaterials is shown in Fig. 1a, from this figure, the prepared material has 14 peaks that characterize it, these peaks located at 21.55, 25.0, 26.44, 27.54, 28.18,…
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A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools
Di Resta, C., Galbiati, S., Carrera, P. & Ferrari, M. Next-generation sequencing approach for the diagnosis of human diseases: open challenges and new opportunities. EJIFCC 29, 4–14 (2018).
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