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  • Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations

    Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations

    In this study, four targeted panels were used to assess variant detection in paired targeted DNA-seq and RNA-seq data generated for the reference samples (Fig. 1). These panels (the Agilent Clear-seq Custom Comprehensive Cancer DNA panels…

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  • Influence of P-wave oblique incidence on seismic response of helical piles in soft soil sites

    Influence of P-wave oblique incidence on seismic response of helical piles in soft soil sites

    Viscous-spring artificial boundary

    In the context of artificial boundaries, the viscous-spring boundary is recognized for its exceptional stability, being free from issues related to low-frequency drift and high-frequency oscillation…

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  • An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

    An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

    Ethics statement and mice

    All experiments were performed in accordance with GV-SOLAS and FELASA guidelines and have been approved by German authorities (Regierungspräsidium Karlsruhe), or according to the guidelines defined by the Home Office and…

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  • Excitation-inhibition balance abnormally shapes structure–function coupling of gray matter in Parkinson’s disease

    Excitation-inhibition balance abnormally shapes structure–function coupling of gray matter in Parkinson’s disease

    Subjects

    We included 102 PD patients and 110 NC patients, recruited from our medical imaging center. All PD patients satisfied UK Parkinson’s Disease Society Brain Bank criteria36, and all included NC subjects had no neurologic and psychiatric…

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  • H2A.Z is essential for oocyte maturation and fertility in female mouse

    H2A.Z is essential for oocyte maturation and fertility in female mouse

  • Schultz, R. M., Stein, P. & Svoboda, P. The oocyte-to-embryo transition in mouse: past, present, and future. Biol. Reprod. 99, 160–174 (2018).

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  • Promises and pitfalls of multi-cancer early detection using liquid biopsy tests

    Promises and pitfalls of multi-cancer early detection using liquid biopsy tests

  • Ferlay, J. et al. Cancer statistics for the year 2020: an overview. Int. J. Cancer https://doi.org/10.1002/ijc.33588 (2021).

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  • World Health Organization. Global health…

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  • H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes

    H2A.Z reinforces maternal H3K4me3 formation and is essential for meiotic progression in mouse oocytes

  • Clift, D. & Schuh, M. Restarting life: fertilization and the transition from meiosis to mitosis. Nat. Rev. Mol. Cell Biol. 14, 549–562 (2013).

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  • Inclusion of medical students in the next generation of clinician scientist training programs

    We appreciate the insights provided by Melk et al. in their Comment1 in Nature Medicine. The authors effectively highlight the importance of structured programs in preparing clinician scientists to bridge the gap between clinical practice and…

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  • FedOcw: optimized federated learning for cross-lingual speech-based Parkinson’s disease detection

    FedOcw: optimized federated learning for cross-lingual speech-based Parkinson’s disease detection

    To evaluate the effectiveness of our proposed federated learning framework for speech-based Parkinson’s disease detection, we utilized five multilingual datasets, incorporating Spanish, Italian, Chinese, Czech, and English speech samples. These…

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