Model structure
A system of ordinary differential equations (ODEs) was specified, consisting of 37 variables and 90 parameters. The model was built in a stepwise fashion by combining two published QSP models, one for the TDB mosunetuzumab24 and…
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The sequence of changes in intravascular imaging findings during lipid-lowering therapy and its implication
Yusuf, S. et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case–control study. Lancet 364, 937–952 (2004).
Google…
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Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity
Protein expression and purification
The clone for expressing the recombinant HCV sE2 has been described previously15,18,55. Expression of CHO sE2 and geCHO.sE2.1 and geCHO.sE2.7 was performed as follows. DNA encoding sE2 was chemically transfected…
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Real-time digital intervention on oral pre-exposure prophylaxis adherence among MSM: randomized controlled trial
Study design and participants
The CROPrEP prospective interventional study assessed HIV prevention efficacy of emtricitabine-tenofovir disoproxil fumarate (F/TDF) among MSM in Shenyang, Beijing, Chongqing, and Shenzhen39. Participants were…
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Single-cell foundation models evaluated | Nature Methods
Inspired by their remarkable success in many areas, foundation models have recently been in the spotlight for method development in computational biology. As an example, single-cell foundation models digest a massive corpus of data aiming to…
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High-resolution lifestyle profiling and metabolic subphenotypes of type 2 diabetes
Study design, participants, and sample collection
Participants were recruited from the San Francisco Bay Area, California. Inclusion criteria were general health, with no prior diabetes diagnosis, no uncontrolled hypertension or major organ…
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Energizing leukaemia | Nature Reviews Cancer
Signals emanating from the bone marrow microenvironment are crucial for the survival, stem cell self-renewal capacity and pathogenesis of haematological malignancies. Yet, many of the local and direct interactions between stromal cells and…
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Acoustic blackbody through instability-induced softening
Instability-induced softening
To realize a cavity with zero static modulus, we introduce instability mechanisms that neutralize the system’s inherent elasticity. The following theoretical framework will characterize how unstable elements…
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AACR 2025 | Nature Reviews Cancer
The 2025 American Association for Cancer Research (AACR) annual meeting was held in Chicago, Illinois, bringing together approximately 21,500 participants from 81 countries under the theme ‘Unifying Cancer Science and Medicine: A Continuum of…
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Intracellular protein editing | Nature Methods
Studying proteins in native cellular contexts provides a more realistic picture of their functions. Most available techniques for studying proteins in mammalian cells require the addition of a tag that enables tracking and visualization of the…
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