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  • Structural basis of GluK2 kainate receptor activation by a partial agonist

    Structural basis of GluK2 kainate receptor activation by a partial agonist

  • Hansen, K. B. et al. Structure, function, and pharmacology of glutamate receptor ion channels. Pharm. Rev. 73, 298–487 (2021).

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  • In vitro and in silico evaluation of fluorinated diphenylamine chalcone derivatives as potential antimalarial and anticancer agents

    In vitro and in silico evaluation of fluorinated diphenylamine chalcone derivatives as potential antimalarial and anticancer agents

    Chemistry

    The chalcones were synthesized by reacting substituted aldehydes with a diphenylamine ketone derivative, specifically 1-(3-((3,4-difluorophenyl)amino)phenyl)ethan-1-one,(RM) in the presence of potassium hydroxide (KOH) as the base and…

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  • Platelet aggregation elicits FasL expression and hepatocyte apoptosis in sinusoidal obstruction syndrome

    Platelet aggregation elicits FasL expression and hepatocyte apoptosis in sinusoidal obstruction syndrome

    Monocrotaline (MCT) was purchased from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan). To prepare the MCT solution, the powder was dissolved in 1.0 N HCl and then adjusted to pH 7.4 with 0.5 N NaOH. A Fas/FasL antagonist, Kp7-6, was…

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  • Load demand forecasting in air conditioning a rotor Hopfield neural network approach optimized by a new optimization algorithm

    Load demand forecasting in air conditioning a rotor Hopfield neural network approach optimized by a new optimization algorithm

    The inspiration for the suggested algorithm has been, first, presented in this section. After that, more detail was given by the use of the mathematical model, and the algorithm’s operation has been demonstrated using a basic cost function.

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  • Investigation and design of the dual specificity of the PRDM9 protein lysine methyltransferase

    Investigation and design of the dual specificity of the PRDM9 protein lysine methyltransferase

    PRDM9 expression and purification

    His-tagged PRDM9 was overexpressed and purified using Ni-NTA affinity chromatography (Fig. 1b). To test the activity of the purified enzyme, SPOT peptide array methylation experiments were performed using H3K4…

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  • Machine tool FEM model correction assisted by dynamic evolution sequence

    Machine tool FEM model correction assisted by dynamic evolution sequence

    DES-based improved kriging surrogate model (DES-kriging)

    Machine tool finite element models typically contain a large number of nodes. To achieve efficient model correction, it is essential to simplify model computations and construct surrogate…

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  • Author Correction: Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain

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  • Construction and performance verification of an automated assembly system for aero engine principal shaft enabled by multi sensor fusion

    Construction and performance verification of an automated assembly system for aero engine principal shaft enabled by multi sensor fusion

    Fig. 2

    The structure of the AAU. (A) is the driving principal. (B) is the exploded view. The structural diagrams were created using ( SolidWorks Professional 2023).

    Aero-engine assembly primary role is fastening the aero-engine parts and LPTR…

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  • Acid Red 88 biodegradation by Cu nanoparticles stabilized on Marinospirillum alkaliphilum strain N

    Acid Red 88 biodegradation by Cu nanoparticles stabilized on Marinospirillum alkaliphilum strain N

    Identification of CuNPs-synthesizing bacterial strain Cu1

    A copper-resistant bacterial isolate was chosen among isolates screened from samples collected from the Songun copper mine to synthesize CuNPs. Figure 1 shows the use of the GenBank…

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