Oral tolerance to food antigens and the microbiota is maintained by peripherally induced regulatory T (pTreg) cells that suppress inflammatory responses in the gut. However, the subsets of antigen-presenting cells (APCs) that instruct regulatory…
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Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment
DNA origami synthesis
The rectangular DNA origami structure with a pillar in the center (Fig. 1b) was designed using CaDNAno52 and it is accessible at https://nanobase.org/structure/14653. It is modified with six biotin staples going out of the…
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The association between maternal smoking during pregnancy and dental development in offspring: a systematic review
Geirdal A, Saltnes SS, Storhaug K, Åsten P, Nordgarden H, Jensen JL. Living with orofacial conditions: psychological distress and quality of life in adults affected with Treacher Collins syndrome, cherubism, or oligodontia/ectodermal dysplasia-a…
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Negotiating risks to natural capital in net-zero transitions
Rogelj, J. et al. Paris Agreement climate proposals need a boost to keep warming well below 2 °C. Nature 534, 631–639 (2016).
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Richardson, K. et al. Earth beyond six…
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Structural determinants for pH-dependent activation of a plant metacaspase
pH-dependent AtMC9 activation for autolysis and structural changes
The AtMC9 zymogen is activated by protons, which lead to autolytic self-cleavage after Arg183 in the linker domain that relieves the autoinhibitory function of the linker, similar…
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Collaborative energy and land use planning
The author is also affiliated with Oak Ridge National Laboratory, which did not provide specific support for this paper. The views and opinions expressed in this paper are those of the author alone and do not necessarily represent those of the…
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A visual–omics foundation model to bridge histopathology with spatial transcriptomics
Training dataset curation
We curated a large dataset of histopathology image–transcriptomics pairs using publicly available 10x Visium datasets (Supplementary Table 1). H&E images were cropped to match ST spot sizes, and text sentences were…
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How the natural world is inspiring the robot eyes of the future
The miniature curved compound eye, called CurvACE, was inspired by the eyes of insects.Credit: Alain Herzog, EPFL
Electrical engineer Young Min Song remembers when his colleague at the Gwangju…
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scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links
Method overview
scMODAL is a deep generative framework that learns integrated cell representations from single-cell multi-omics features. The input to scMODAL comprises cell-by-feature data matrices. For simplicity, we consider the scenario…
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ACE2: accurately learning subseasonal to decadal atmospheric variability and forced responses
Training period evaluation
We present ACE2 model evaluations initialized in January 1940 and run forward for 81 years through December 2020, spanning nearly the full period of ERA5 and SHiELD data. Although this period overlaps with the training…
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