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Mutation in an enzyme leads to resistance to chronic and…
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Tazobactam selects for multidrug resistance
Multiple efflux systems affect susceptibility to tazobactam, but only AcrAB affects piperacillin susceptibility
The TraDIS-Xpress data identified 41 genes that affected the susceptibility of E. coli to piperacillin, 74 to tazobactam and 108 to a…
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Uncertainty evaluation and model optimization in multi-source reservoir modeling
Partition blocks
The seismic response characteristics across different zones of the study area are distinctly different. In the root area of the fan delta, the reservoir is thick with almost no shale, exhibiting broad and weak reflections, without…
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Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy
This study complied with all relevant ethical regulations. The research protocol was approved by the Institutional Ethics Review Board of the First Affiliated Hospital of China Medical University (No. [2022]366). The export of the relevant…
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See the Milky Way dazzle during a lunar eclipse — May’s best science images
Plumes of smoke. This image, captured by the European Space Agency’s Copernicus Sentinel-2 satellite, shows smoke from the Lac du Bonnet wildfire rising above Manitoba, Canada, where it resulted in two fatalities, forced…
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Role-playing after 6 pm: conceptualization, scale development, and validation of formalistic overtime behavior in the Chinese workplace
Study 2: exploratory factor analysis (EFA)
Participants and procedures
Study 2 recruited 400 adult white-collar full-time employees from China through Credamo. Additionally, we required participants to have experienced at least four unpaid overtime…
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Impact of antibacterial therapeutic agents on biofilm-tissue interactions in a 3D implant-tissue-oral-bacterial-biofilm model
Henry, P. J. Oral implant restoration for enhanced oral function. Clin. Exp. Pharmacol. Physiol. 32, 123–127 (2005).
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Ritzert, B. Zahnimplantate zunehmend erste…
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Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers
RNAi-mediated β-catenin inhibition results in potent CTNNB1 knockdown in vitro and in vivo
To study the effects of RNAi-mediated inhibition in β-catenin-mutated HCC, we utilized a novel siRNA that targets the CTNNB1 gene, with both mouse and…
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